Seroatlas · Human Serome Atlas

PNLDC1

Poly(A)-specific ribonuclease PNLDC1

Also known as: dJ195P10.2, FLJ40240, PNDC1_HUMAN, Trimmer

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NA58
Gene: PNLDC1
Ensembl: ENSG00000146453
Chromosome: 6
Canonical length: 520 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

Enables poly(A)-specific ribonuclease activity. Involved in nuclear-transcribed mRNA poly(A) tail shortening; piRNA processing; and spermatogenesis. Located in endoplasmic reticulum. Implicated in spermatogenic failure 57. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q8NA58|PNLDC1
     1  MFCTRGLLFF AFLAGLDIEF TGLRSNLSGP QQISLFDLPS EWYLKTRQSV QQFTVCQIGL
    61  SVFSAIEGEA NKYIAHSCNF YLFPTTFGIL DSEFSFQASS VQFLNQYGFN YNKFLKNGIP
   121  YMNEEQEKKI RHDILTGNWR VRSSPDKDQI KVVIDEVTRW LELAKEGDWM TLPGITGFQA
   181  FEVQLVLRQA LPNIWTVLKD EGVVVKKVSK QHRWYLQNTS CDRESCWKEN ILLSARGFSV
   241  FFQMLVKAQK PLVGHNMMMD LLHLHEKFFR PLPESYDQFK QNIHSLFPVL IDTKSVTKDI
   301  WKEMNFPRVS NLSEVYEVLN SDLNPTKNSG PEIVHASRCE KYVETKCPHE AAYDAFLCGS
   361  VLLKVAHLLL QKIYHIDPVP ESSFPQYLDV LAPYVNQVNL IRAGVPKINF SGPDYPSIRP
   421  PILILSVKRW PGVSEQQVYH KFQNLCKFDV RRLTRSQFLL LTNKFKDARN ILKEYRDHPT
   481  LCISLYRYWR HSPNVNCLLQ VCGIVTAWAL LAFILGRSGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PNLDC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

testis: 7.9 nTPM
basal ganglia: 3.6 nTPM
cerebral cortex: 1.8 nTPM
fallopian tube: 1.8 nTPM
pancreas: 1.6 nTPM
ovary: 1.2 nTPM

Single-cell type

oocytes: 281 nCPM
late primary spermatocytes: 25 nCPM
undifferentiated spermatogonia: 22 nCPM
late spermatids: 22 nCPM
early spermatids: 22 nCPM
pancreatic duct cells: 21 nCPM

Immune cell

plasmacytoid DC: 0.3 nTPM
intermediate monocyte: 0.2 nTPM
myeloid DC: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 17 nTPM
basal ganglia: 4.7 nTPM
pons: 2.9 nTPM
white matter: 2.6 nTPM
cerebellum: 2.1 nTPM
thalamus: 1.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PNLDC1.

Disease | AllUniProt

Conditions PNLDC1 is implicated in, by any mechanism.

Spermatogenic failure 57 (SPGF57) MIM:619528

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 57
Male infertility with azoospermia or oligozoospermia due to single gene mutation
Non-obstructive azoospermia
Oligospermia
Male infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PNLDC1 as an antibody target. Whether an autoantibody or antibody against PNLDC1 could matter depends on whether native PNLDC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PNLDC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PNLDC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...