Seroatlas · Human Serome Atlas

TEFM

Transcription elongation factor, mitochondrial

Also known as: C17orf42, FLJ22729, TEFM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96QE5
Gene: TEFM
Ensembl: ENSG00000172171
Chromosome: 17
Canonical length: 360 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Enables transcription elongation factor activity. Involved in positive regulation of mitochondrial transcription and regulation of oxidative phosphorylation. Located in mitochondrial nucleoid. Part of ribonucleoprotein complex. Implicated in combined oxidative phosphorylation deficiency. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q96QE5|TEFM
     1  MSGSVLFTAG ERWRCFLTPS RSSLYWALHN FCCRKKSTTP KKITPNVTFC DENAKEPENA
    61  LDKLFSSEQQ ASILHVLNTA STKELEAFRL LRGRRSINIV EHRENFGPFQ NLESLMNVPL
   121  FKYKSTVQVC NSILCPKTGR EKRKSPENRF LRKLLKPDIE RERLKAVNSI ISIVFGTRRI
   181  AWAHLDRKLT VLDWQQSDRW SLMRGIYSSS VYLEEISSII SKMPKADFYV LEKTGLSIQN
   241  SSLFPILLHF HIMEAMLYAL LNKTFAQDGQ HQVLSMNRNA VGKHFELMIG DSRTSGKELV
   301  KQFLFDSILK ADPRVFFPSD KIVHYRQMFL STELQRVEEL YDSLLQAIAF YELAVFDSQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TEFM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

tongue: 11 nTPM
kidney: 8.9 nTPM
heart muscle: 8.8 nTPM
liver: 8.2 nTPM
skeletal muscle: 7.9 nTPM
spleen: 7.3 nTPM

Single-cell type

myonuclei: 53 nCPM
leydig cells: 51 nCPM
cone photoreceptor cells: 50 nCPM
fibro-adipogenic progenitors: 49 nCPM
bergmann glia: 47 nCPM
microglia: 46 nCPM

Immune cell

intermediate monocyte: 12 nTPM
T-reg: 10 nTPM
naive CD4 T-cell: 10 nTPM
non-classical monocyte: 10 nTPM
memory B-cell: 9.8 nTPM
naive CD8 T-cell: 9.2 nTPM

Brain region

cerebellum: 7.5 nTPM
choroid plexus: 7.1 nTPM
white matter: 6 nTPM
pons: 5.3 nTPM
thalamus: 5.2 nTPM
basal ganglia: 5.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TEFM.

Disease | AllUniProt

Conditions TEFM is implicated in, by any mechanism.

Combined oxidative phosphorylation deficiency 58 (COXPD58) MIM:620451

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.51
gnomAD missense Z: 0.58
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of mitochondrial transcription
regulation of oxidative phosphorylation
transcription elongation by mitochondrial RNA polymerase

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RuvA domain 2-like
Ribonuclease H-like superfamily
Ribonuclease H superfamily
Helix-hairpin-helix motif
Transcription elongation factor, mitochondrial

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TEFM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TEFM as an antibody target. Whether an autoantibody or antibody against TEFM could matter depends on whether native TEFM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TEFM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TEFM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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