Seroatlas · Human Serome Atlas

ZMYM6

Zinc finger MYM-type protein 6

Also known as: Buster2, KIAA1353, MYM, ZBED7, ZMYM6_HUMAN, ZNF198L4, ZNF258

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95789
Gene: ZMYM6
Ensembl: ENSG00000163867
Chromosome: 1
Canonical length: 1325 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity. Involved in cytoskeleton organization and regulation of cell morphogenesis. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1325 residues, UniProt reviewed canonical sequence.

>O95789|ZMYM6
     1  MKEPLDGECG KAVVPQQELL DKIKEEPDNA QEYGCVQQPK TQESKLKIGG VSSVNERPIA
    61  QQLNPGFQLS FASSGPSVLL PSVPAVAIKV FCSGCKKMLY KGQTAYHKTG STQLFCSTRC
   121  ITRHSSPACL PPPPKKTCTN CSKDILNPKD VITTRFENSY PSKDFCSQSC LSSYELKKKP
   181  VVTIYTKSIS TKCSMCQKNA DTRFEVKYQN VVHGLCSDAC FSKFHSTNNL TMNCCENCGS
   241  YCYSSSGPCQ SQKVFSSTSV TAYKQNSAQI PPYALGKSLR PSAEMIETTN DSGKTELFCS
   301  INCLSAYRVK TVTSSGVQVS CHSCKTSAIP QYHLAMSNGT IYSFCSSSCV VAFQNVFSKP
   361  KGTNSSAVPL SQGQVVVSPP SSRSAVSIGG GNTSAVSPSS IRGSAAASLQ PLAEQSQQVA
   421  LTHTVVKLKC QHCNHLFATK PELLFYKGKM FLFCGKNCSD EYKKKNKVVA MCDYCKLQKI
   481  IKETVRFSGV DKPFCSEVCK FLSARDFGER WGNYCKMCSY CSQTSPNLVE NRLEGKLEEF
   541  CCEDCMSKFT VLFYQMAKCD GCKRQGKLSE SIKWRGNIKH FCNLFCVLEF CHQQIMNDCL
   601  PQNKVNISKA KTAVTELPSA RTDTTPVITS VMSLAKIPAT LSTGNTNSVL KGAVTKEAAK
   661  IIQDESTQED AMKFPSSQSS QPSRLLKNKG ISCKPVTQTK ATSCKPHTQH KECQTDLPMP
   721  NEKNDAELDS PPSKKKRLGF FQTYDTEYLK VGFIICPGSK ESSPRPQCVI CGEILSSENM
   781  KPANLSHHLK TKHSELENKP VDFFEQKSLE MECQNSSLKK CLLVEKSLVK ASYLIAFQTA
   841  ASKKPFSIAE ELIKPYLVEM CSEVLGSSAG DKMKTIPLSN VTIQHRIDEL SADIEDQLIQ
   901  KVRESKWFAL QIDESSEISN ITLLLCYIRF IDYDCRDVKE ELLFCIEMPT QITGFEIFEL
   961  INKYIDSKSL NWKHCVGLCT DGAASMTGRY SGLKAKIQEV AMNTAAFTHC FIHRERLVAE
  1021  KLSPCLHKIL LQSAQILSFI KSNALNSRML TILCEEMGSE HVSLPLHAEV RWISRGRMLK
  1081  RLFELRHEIE IFLSQKHSDL AKYFHDEEWV GKLAYLSDIF SLINELNLSL QGTLTTFFNL
  1141  CNKIDVFKRK LKMWLKRTQE NDYDMFPSFS EFSNSSGLNM TDITRIIFEH LEGLSQVFSD
  1201  CFPPEQDLRS GNLWIIHPFM NHQNNNLTDF EEEKLTELSS DLGLQALFKS VSVTQFWINA
  1261  KTSYPELHER AMKFLLPFST VYLCDAAFSA LTESKQKNLL GSGPALRLAV TSLIPRIEKL
  1321  VKEKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 15 nTPM
spleen: 9.9 nTPM
lymph node: 8.9 nTPM
testis: 8.9 nTPM
thyroid gland: 8.8 nTPM
retina: 8.6 nTPM

Single-cell type

microglia: 109 nCPM
oligodendrocytes: 53 nCPM
brain inhibitory neurons: 50 nCPM
astrocytes: 49 nCPM
choroid plexus epithelial cells: 44 nCPM
bergmann glia: 44 nCPM

Immune cell

plasmacytoid DC: 7.5 nTPM
non-classical monocyte: 5.7 nTPM
eosinophil: 5.5 nTPM
naive B-cell: 5.4 nTPM
classical monocyte: 5.3 nTPM
gdT-cell: 5.1 nTPM

Brain region

cerebellum: 17 nTPM
white matter: 16 nTPM
thalamus: 16 nTPM
basal ganglia: 15 nTPM
pons: 15 nTPM
cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 1.7
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYM6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYM6 as an antibody target. Whether an autoantibody or antibody against ZMYM6 could matter depends on whether native ZMYM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYM6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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