Seroatlas · Human Serome Atlas

SUPT6H

Transcription elongation factor SPT6

Also known as: KIAA0162, SPT6H, SPT6H_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7KZ85
Gene: SUPT6H
Ensembl: ENSG00000109111
Chromosome: 17
Canonical length: 1726 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Enables histone binding activity. Involved in positive regulation of transcription elongation by RNA polymerase II and transcription elongation-coupled chromatin remodeling. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1726 residues, UniProt reviewed canonical sequence.

>Q7KZ85|SUPT6H
     1  MSDFVESEAE ESEEEYNDEG EVVPRVTKKF VEEEDDDEEE EEENLDDQDE QGNLKGFIND
    61  DDDEDEGEED EGSDSGDSED DVGHKKRKRT SFDDRLEDDD FDLIEENLGV KVKRGQKYRR
   121  VKKMSDDEDD DEEEYGKEEH EKEAIAEEIF QDGEGEEGQE AMEAPMAPPE EEEEDDEESD
   181  IDDFIVDDDG QPLKKPKWRK KLPGYTDAAL QEAQEIFGVD FDYDEFEKYN EYDEELEEEY
   241  EYEDDEAEGE IRVRPKKTTK KRVSRRSIFE MYEPSELESS HLTDQDNEIR ATDLPERFQL
   301  RSIPVKGAED DELEEEADWI YRNAFATPTI SLQESCDYLD RGQPASSFSR KGPSTIQKIK
   361  EALGFMRNQH FEVPFIAFYR KEYVEPELHI NDLWRVWQWD EKWTQLRIRK ENLTRLFEKM
   421  QAYQYEQISA DPDKPLADGI RALDTTDMER LKDVQSMDEL KDVYNHFLLY YGRDIPKMQN
   481  AAKASRKKLK RVREEGDEEG EGDEAEDEEQ RGPELKQASR RDMYTICQSA GLDGLAKKFG
   541  LTPEQFGENL RDSYQRHETE QFPAEPLELA KDYVCSQFPT PEAVLEGARY MVALQIAREP
   601  LVRQVLRQTF QERAKLNITP TKKGRKDVDE AHYAYSFKYL KNKPVKELRD DQFLKICLAE
   661  DEGLLTTDIS IDLKGVEGYG NDQTYFEEIK QFYYRDEFSH QVQEWNRQRT MAIERALQQF
   721  LYVQMAKELK NKLLAEAKEY VIKACSRKLY NWLRVAPYRP DQQVEEDDDF MDENQGKGIR
   781  VLGIAFSSAR DHPVFCALVN GEGEVTDFLR LPHFTKRRTA WREEEREKKA QDIETLKKFL
   841  LNKKPHVVTV AGENRDAQML IEDVKRIVHE LDQGQQLSSI GVELVDNELA ILYMNSKKSE
   901  AEFRDYPPVL RQAVSLARRI QDPLIEFAQV CSSDEDILCL KFHPLQEHVV KEELLNALYC
   961  EFINRVNEVG VDVNRAIAHP YSQALIQYVC GLGPRKGTHL LKILKQNNTR LESRTQLVTM
  1021  CHMGPKVFMN CAGFLKIDTA SLGDSTDSYI EVLDGSRVHP ETYEWARKMA VDALEYDESA
  1081  EDANPAGALE EILENPERLK DLDLDAFAEE LERQGYGDKH ITLYDIRAEL SCRYKDLRTA
  1141  YRSPNTEEIF NMLTKETPET FYIGKLIICN VTGIAHRRPQ GESYDQAIRN DETGLWQCPF
  1201  CQQDNFPELS EVWNHFDSGS CPGQAIGVKT RLDNGVTGFI PTKFLSDKVV KRPEERVKVG
  1261  MTVHCRIMKI DIEKFSADLT CRTSDLMDRN NEWKLPKDTY YDFDAEAADH KQEEDMKRKQ
  1321  QRTTYIKRVI AHPSFHNINF KQAEKMMETM DQGDVIIRPS SKGENHLTVT WKVSDGIYQH
  1381  VDVREEGKEN AFSLGATLWI NSEEFEDLDE IVARYVQPMA SFARDLLNHK YYQDCSGGDR
  1441  KKLEELLIKT KKEKPTFIPY FICACKELPG KFLLGYQPRG KPRIEYVTVT PEGFRYRGQI
  1501  FPTVNGLFRW FKDHYQDPVP GITPSSSSRT RTPASINATP ANINLADLTR AVNALPQNMT
  1561  SQMFSAIAAV TGQGQNPNAT PAQWASSQYG YGGSGGGSSA YHVFPTPAQQ PVATPLMTPS
  1621  YSYTTPSQPI TTPQYHQLQA STTPQSAQAQ PQPSSSSRQR QQQPKSNSHA AIDWGKMAEQ
  1681  WLQEKEAERR KQKQRLTPRP SPSPMIESTP MSIAGDATPL LDEMDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUPT6H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 62 nTPM
skeletal muscle: 52 nTPM
blood vessel: 38 nTPM
skin: 37 nTPM
colon: 35 nTPM
liver: 35 nTPM

Single-cell type

neutrophils: 345 nCPM
monocytes: 133 nCPM
syncytiotrophoblasts: 126 nCPM
neutrophil progenitors: 116 nCPM
cone photoreceptor cells: 114 nCPM
ocular epithelial cells: 110 nCPM

Immune cell

basophil: 15 nTPM
neutrophil: 6.8 nTPM
plasmacytoid DC: 6.2 nTPM
non-classical monocyte: 5.1 nTPM
classical monocyte: 4.5 nTPM
memory B-cell: 4.5 nTPM

Brain region

cerebral cortex: 67 nTPM
hypothalamus: 64 nTPM
thalamus: 60 nTPM
choroid plexus: 59 nTPM
midbrain: 57 nTPM
basal ganglia: 56 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SUPT6H.

Disease | ImmuneIEDB

Conditions an epitope on SUPT6H was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.09
gnomAD pLI: 1
gnomAD missense Z: 5.14
DepMap mean gene effect: -1.84
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

SH2 domain
S1 domain
YqgF/RNase H-like domain
RuvA domain 2-like
Ribonuclease H-like superfamily
Nucleic acid-binding, OB-fold
Tex-like protein, HTH domain superfamily
Tex-like domain superfamily
SH2 domain superfamily
YqgF/RNase H-like domain superfamily
HHH domain 9
Tex-like, central region
S1 RNA binding domain
HHH domain
Tex central region-like
Transcription elongation factor Spt6
Spt6 acidic, N-terminal domain
Helix-turn-helix DNA-binding domain of Spt6
Transcription elongation factor Spt6, YqgF domain
Transcription elongation factor Spt6, helix-hairpin-helix motif
Spt6, SH2 domain, C terminus
Spt6, SH2 domain, N terminus
Spt6, SH2 domain
Spt6, Death-like domain
Acidic N-terminal SPT6
SH2 domain
Helix-hairpin-helix motif
Holliday-junction resolvase-like of SPT6
Helix-turn-helix DNA-binding domain of SPT6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUPT6H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUPT6H as an antibody target. Whether an autoantibody or antibody against SUPT6H could matter depends on whether native SUPT6H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUPT6H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUPT6H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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