SRBD1

Protein identityUniProt · HPA

UniProt accession

Q8N5C6

Gene

SRBD1

Ensembl

ENSG00000068784

Chromosome

2

Canonical length

995 aa

Protein class

Predicted intracellular proteins

Subcellular location

Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

995 residues, UniProt reviewed canonical sequence.

>Q8N5C6|SRBD1
     1  MSSLPRRAKV QVQDVVLKDE FSSFSELSSA SEEDDKEDSA WEPQKKVPRS RKQPPPKESK
    61  PKRMPRVKKN APQISDGSEV VVVKEELNSS VAIADTALED RKNKLDTVQT LKTAKTKQKC
   121  AAQPHTVRRT KKLKVEEETS KASNLEGESN SSETPSTSTV WGGTCKKEEN DDDFTFGQSA
   181  LKKIKTETYP QGQPVKFPAN ANSTKEEVEM NWDMVQVLSE RTNIEPWVCA NIIRLFNDDN
   241  TIPFIIRYRK ELINNLDADS LREVQQTLEE LRAVAKKVHS TIQKIKKEGK MSECLLKAML
   301  NCKTFEELEH VSAPYKTGSK GTKAQRARQL GLEGAARALL EKPGELSLLS YIRPDVKGLS
   361  TLQDIEIGVQ HILADMIAKD KDTLDFIRNL CQKRHVCIQS SLAKVSSKKV NEKDVDKFLL
   421  YQHFSCNIRN IHHHQILAIN RGENLKVLTV KVNISDGVKD EFCRWCIQNR WRPRSFARPE
   481  LMKILYNSLN DSFKRLIYPL LCREFRAKLT SDAEKESVMM FGRNLRQLLL TSPVPGRTLM
   541  GVDPGYKHGC KLAIISPTSQ ILHTDVVYLH CGQGFREAEK IKTLLLNFNC STVVIGNGTA
   601  CRETEAYFAD LIMKNYFAPL DVVYCIVSEA GASIYSVSPE ANKEMPGLDP NLRSAVSIAR
   661  RVQDPLAELV KIEPKHIGVG MYQHDVSQTL LKATLDSVVE ECVSFVGVDI NICSEVLLRH
   721  IAGLNANRAK NIIEWREKNG PFINREQLKK VKGLGPKSFQ QCAGFIRINQ DYIRTFCSQQ
   781  TETSGQIQGV AVTSSADVEV TNEKQGKKKS KTAVNVLLKP NPLDQTCIHP ESYDIAMRFL
   841  SSIGGTLYEV GKPEMQQKIN SFLEKEGMEK IAERLQTTVH TLQVIIDGLS QPESFDFRTD
   901  FDKPDFKRSI VCLEDLQIGT VLTGKVENAT LFGIFVDIGV GKSGLIPIRN VTEAKLSKTK
   961  KRRSLGLGPG ERVEVQVLNI DIPRSRITLD LIRVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRBD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.98

gnomAD pLI

0

gnomAD missense Z

-1.85

DepMap mean gene effect

-1.53

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• nucleobase-containing compound metabolic process
• translation

Molecular functions

• mRNA binding
• structural constituent of ribosome

Protein domainsUniProt · Pfam · InterPro

• S1 domain
• YqgF/RNase H-like domain
• RuvA domain 2-like
• Ribonuclease H-like superfamily
• Nucleic acid-binding, OB-fold
• Tex-like protein, HTH domain superfamily
• Tex-like domain superfamily
• YqgF/RNase H-like domain superfamily
• HHH domain 9
• Tex-like, central region
• S1 RNA binding domain
• Helix-hairpin-helix motif
• HHH domain
• Tex central region-like
• Tex-like protein, N-terminal
• Tex protein, YqgF-like domain
• Tex, S1 domain
• Small ribosomal subunit protein bS1-like
• Tex-like protein N-terminal domain
• Tex protein YqgF-like domain

KeywordsUniProt

• Chromosome
• Coiled coil
• Cytoplasm
• Isopeptide bond
• Nucleus
• Phosphoprotein
• RNA-binding
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of SRBD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• NBR1
• PARP1