ZBED4

Protein identityUniProt · HPA

UniProt accession

O75132

Gene

ZBED4

Ensembl

ENSG00000100426

Chromosome

22

Canonical length

1171 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1171 residues, UniProt reviewed canonical sequence.

>O75132|ZBED4
     1  MENNLKTCPK EDGDFVSDKI KFKIEEEDDD GIPPDSLERM DFKSEQEDMK QTDSGGERAG
    61  LGGTGCSCKP PGKYLSAESE DDYGALFSQY SSTLYDVAME AVTQSLLSSR NMSSRKKSPA
   121  WKHFFISPRD STKAICMYCV KEFSRGKNEK DLSTSCLMRH VRRAHPTVLI QENGSVSAVS
   181  SFPSPSLLLP PQPADAGDLS TILSPIKLVQ KVASKIPSPD RITEESVSVV SSEEISSDMS
   241  VSEKCGREEA LVGSSPHLPA LHYDEPAENL AEKSLPLPKS TSGSRRRSAV WKHFYLSPLD
   301  NSKAVCIHCM NEFSRGKNGK DLGTSCLIRH MWRAHRAIVL QENGGTGIPP LYSTPPTLLP
   361  SLLPPEGELS SVSSSPVKPV RESPSASSSP DRLTEDLQSH LNPGDGLMED VAAFSSSDDI
   421  GEASASSPEK QQADGLSPRL FESGAIFQQN KKVMKRLKSE VWHHFSLAPM DSLKAECRYC
   481  GCAISRGKKG DVGTSCLMRH LYRRHPEVVG SQKGFLGASL ANSPYATLAS AESSSSKLTD
   541  LPTVVTKNNQ VMFPVNSKKT SKLWNHFSIC SADSTKVVCL HCGRTISRGK KPTNLGTSCL
   601  LRHLQRFHSN VLKTEVSETA RPSSPDTRVP RGTELSGASS FDDTNEKFYD SHPVAKKITS
   661  LIAEMIALDL QPYSFVDNVG FNRLLEYLKP QYSLPAPSYF SRTAIPGMYD NVKQIIMSHL
   721  KEAESGVIHF TSGIWMSNQT REYLTLTAHW VSFESPARPR CDDHHCSALL DVSQVDCDYS
   781  GNSIQKQLEC WWEAWVTSTG LQVGITVTDN ASIGKTLNEG EHSSVQCFSH TVNLIVSEAI
   841  KSQRMVQNLL SLARKICERV HRSPKAKEKL AELQREYALP QHHLIQDVPS KWSTSFHMLE
   901  RLIEQKRAIN EMSVECNFRE LISCDQWEVM QSVCRALKPF EAASREMSTQ MSTLSQVIPM
   961  VHILNRKVEM LFEETMGIDT MLRSLKEAMV SRLSATLHDP RYVFATLLDP RYKASLFTEE
  1021  EAEQYKQDLI RELELMNSTS EDVAASHRCD AGSPSKDSAA EENLWSLVAK VKKKDPREKL
  1081  PEAMVLAYLE EEVLEHSCDP LTYWNLKKAS WPGLSALAVR FLGCPPSIVP SEKLFNTPTE
  1141  NGSLGQSRLM MEHFEKLIFL KVNLPLIYFQ Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBED4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

10 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZBED4.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 191 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Short stature

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.41

gnomAD pLI

0.51

gnomAD missense Z

2.26

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity, RNA polymerase II-specific
• identical protein binding
• protein dimerization activity
• RNA binding
• RNA polymerase II transcription regulatory region sequence-specific DNA binding
• transcription cis-regulatory region binding
• zinc ion binding

Cellular components

• chromatin
• cytoplasm
• nucleoplasm
• nucleus
• photoreceptor inner segment

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, BED-type
• HAT, C-terminal dimerisation domain
• Ribonuclease H-like superfamily
• Zinc finger C2H2 superfamily
• BED zinc finger
• hAT family C-terminal dimerisation region
• Zinc finger BED domain-containing

KeywordsUniProt

• Activator
• Cytoplasm
• DNA-binding
• Isopeptide bond
• Metal-binding
• Nucleus
• Phosphoprotein
• Repeat
• RNA-binding
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZBED4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MYH9
• SAFB