ERVK-25
Endogenous retrovirus group K member 25 Pol protein
Also known as: POK25_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for ERVK-25 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
954 residues, UniProt reviewed canonical sequence.
>P63136|ERVK-25
1 NKSKKRRNRV SFLGAATVEP PKPIPLTWKT EKPVWVNQWP LPKQKLEALH LLANEQLEKG
61 HIEPSFSPWN SPVFVIQKKS GKWRMLTDLR AVNAVIQPMG PLQPGLPSPA MIPKDWPLII
121 IDLKDCFFTI PLAEQDCEKF AFTIPAINNK EPATRFQWKV LPQGMLNSPT ICQTFVGRAL
181 QPVREKFSDC YIIHYIDDIL CAAETKDKLI DCYTFLQAEV ANAGLAIASD KIQTSTPFHY
241 LGMQIENRKI KPQKIEIRKD TLKALNDFQK LLGDINWIRP TLGIPTYAMS NLFSILRGDS
301 DLNSKRMLTP EATKEIKLVE EKIQSAQINR IDPLAPLQLL IFATAHSPTG IIIQNTDLVE
361 WSFLPHSTVK TFTLYLDQIA TLIGQTRLRI IKLCGNDPDK IVVPLTKEQV RQAFINSGAW
421 QIGLANFVGI IDNHYPKTKI FQFLKLTTWI LPKITRREPL ENALTVFTDG SSNGKAAYTG
481 PKERVIKTPY QSAQRAELVA VITVLQDFDI NIISDSAYVV QATRDVETAL IKYSMDDQLN
541 QLFNLLQQTV RKRNFPFYIT HIRAHTNLPG PLTKANKQAD LLVSSALIKA QELHALTHVN
601 AAGLKNKFDV TWKLAKDIVQ HCTQCQVLHL PTQEAGVNPR GLCPNALWQM DVTHVPSFGR
661 LSYVHVTVDT YSHFIWATCH TGESTSHVKK HLLSCFAVMG VPEKIKTDNG PGYCSKAFQK
721 FLSQWKISHT TGIPYNSQGQ AIVERTNRTL KTQLVKQKEG GDSKECTTPQ MQLNLALYTL
781 NFLNIYRNQT TTSAEQHLTG KKNSPHEGKL IWWKDNKNKT WEIGKVITWG RGFACVSPGE
841 NQLPVWIPTR HLKFYNEPIR DAKKSTSAET ETPQSSTVDS QDEQNGDVRR TDEVAIHQEG
901 RAANLGTTKE ADAVSYKISR EHKGDTNPRE YAACSLDDCI NGGKSPYACR SSCSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ERVK-25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Reverse transcriptase domain
- Integrase, C-terminal, retroviral
- Integrase, catalytic core
- Ribonuclease H domain
- Integrase, N-terminal zinc-binding domain
- Reverse transcriptase thumb
- Ribonuclease H-like superfamily
- Integrase-like, N-terminal
- Ribonuclease H superfamily
- Integrase, C-terminal domain superfamily, retroviral
- Reverse transcriptase/Diguanylate cyclase domain
- DNA/RNA polymerase superfamily
- RNase H
- Reverse transcriptase (RNA-dependent DNA polymerase)
- Integrase DNA binding domain
- Integrase core domain
- Integrase Zinc binding domain
- Reverse transcriptase thumb domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ERVK-25 as an antibody target. Whether an autoantibody or antibody against ERVK-25 could matter depends on whether native ERVK-25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ERVK-25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ERVK-25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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