Seroatlas · Human Serome Atlas

ZMYM1

Zinc finger MYM-type protein 1

Also known as: FLJ23151, MYM, ZMYM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5SVZ6
Gene: ZMYM1
Ensembl: ENSG00000197056
Chromosome: 1
Canonical length: 1142 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centriolar satellite

OverviewNCBI Gene

Predicted to enable protein dimerization activity and zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1142 residues, UniProt reviewed canonical sequence.

>Q5SVZ6|ZMYM1
     1  MKEPLLGGEC DKAVASQLGL LDEIKTEPDN AQEYCHRQQS RTQENELKIN AVFSESASQL
    61  TAGIQLSLAS SGVNKMLPSV STTAIQVSCA GCKKILQKGQ TAYQRKGSAQ LFCSIPCITE
   121  YISSASSPVP SKRTCSNCSK DILNPKDVIS VQLEDTTSCK TFCSLSCLSS YEEKRKPFVT
   181  ICTNSILTKC SMCQKTAIIQ YEVKYQNVKH NLCSNACLSK FHSANNFIMN CCENCGTYCY
   241  TSSSLSHILQ MEGQSHYFNS SKSITAYKQK PAKPLISVPC KPLKPSDEMI ETTSDLGKTE
   301  LFCSINCFSA YSKAKMESSS VSVVSVVHDT STELLSPKKD TTPVISNIVS LADTDVALPI
   361  MNTDVLQDTV SSVTATADVI VDLSKSSPSE PSNAVASSST EQPSVSPSSS VFSQHAIGSS
   421  TEVQKDNMKS MKISDELCHP KCTSKVQKVK GKSRSIKKSC CADFECLENS KKDVAFCYSC
   481  QLFCQKYFSC GRESFATHGT SNWKKTLEKF RKHEKSEMHL KSLEFWREYQ FCDGAVSDDL
   541  SIHSKQIEGN KKYLKLIIEN ILFLGKQCLP LRGNDQSVSS VNKGNFLELL EMRAKDKGEE
   601  TFRLMNSQVD FYNSTQIQSD IIEIIKTEML QDIVNEINDS SAFSIICDET INSAMKEQLS
   661  ICVRYPQKSS KAILIKERFL GFVDTEEMTG THLHRTIKTY LQQIGVDMDK IHGQAYDSTT
   721  NLKIKFNKIA AEFKKEEPRA LYIHCYAHFL DLSIIRFCKE VKELRSALKT LSSLFNTICM
   781  SGEMLANFRN IYRLSQNKTC KKHISQSCWT VHDRTLLSVI DSLPEIIETL EVIASHSSNT
   841  SFADELSHLL TLVSKFEFVF CLKFLYRVLS VTGILSKELQ NKTIDIFSLS SKIEAILECL
   901  SSERNDVYFK TIWDGTEEIC QKITCKGFKV EKPSLQKRRK IQKSVDLGNS DNMFFPTSTE
   961  EQYKINIYYQ GLDTILQNLK LCFSEFDYCK IKQISELLFK WNEPLNETTA KHVQEFYKLD
  1021  EDIIPELRFY RHYAKLNFVI DDSCINFVSL GCLFIQHGLH SNIPCLSKLL YIALSWPITS
  1081  ASTENSFSTL PRLKTYLCNT MGQEKLTGPA LMAVEQELVN KLMEPERLNE IVEKFISQMK
  1141  EI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 4.3 nTPM

Expression across tissuesHPA

Tissue

ovary: 4.3 nTPM
breast: 4.2 nTPM
epididymis: 4.1 nTPM
skin: 4 nTPM
thymus: 3.8 nTPM
testis: 3.7 nTPM

Single-cell type

early primary spermatocytes: 71 nCPM
choroid plexus epithelial cells: 62 nCPM
myonuclei: 51 nCPM
fibro-adipogenic progenitors: 50 nCPM
renal collecting duct intercalated cells: 43 nCPM
distal convoluted tubule cells: 42 nCPM

Immune cell

basophil: 5.6 nTPM
NK-cell: 3.1 nTPM
non-classical monocyte: 2.7 nTPM
MAIT T-cell: 2 nTPM
gdT-cell: 1.8 nTPM
memory CD4 T-cell: 1.5 nTPM

Brain region

choroid plexus: 7.8 nTPM
white matter: 6.4 nTPM
cerebellum: 6.2 nTPM
medulla oblongata: 5.5 nTPM
spinal cord: 5.5 nTPM
midbrain: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 1.5
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CTCF

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYM1 as an antibody target. Whether an autoantibody or antibody against ZMYM1 could matter depends on whether native ZMYM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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