Seroatlas · Human Serome Atlas

CNOT7

CCR4-NOT transcription complex subunit 7

Also known as: CAF1, CNOT7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UIV1
Gene
CNOT7
Ensembl
ENSG00000198791
Chromosome
8
Canonical length
285 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q9UIV1|CNOT7
     1  MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY
    61  QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG
   121  IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD
   181  FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK
   241  MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CNOT7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 75 nTPM
  • skeletal muscle: 74 nTPM
  • retina: 72 nTPM
  • tongue: 67 nTPM
  • tonsil: 61 nTPM
  • parathyroid gland: 59 nTPM

Single-cell type

  • oocytes: 175 nCPM
  • parietal cells: 140 nCPM
  • extravillous trophoblasts: 139 nCPM
  • rod photoreceptor cells: 128 nCPM
  • migrating cytotrophoblasts: 120 nCPM
  • gastric chief cells: 119 nCPM

Immune cell

  • basophil: 139 nTPM
  • naive CD4 T-cell: 137 nTPM
  • naive B-cell: 136 nTPM
  • T-reg: 135 nTPM
  • memory B-cell: 134 nTPM
  • total PBMC: 131 nTPM

Brain region

  • cerebral cortex: 83 nTPM
  • cerebellum: 81 nTPM
  • hypothalamus: 64 nTPM
  • basal ganglia: 60 nTPM
  • midbrain: 57 nTPM
  • white matter: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
2.63
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CNOT7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CNOT7 as an antibody target. Whether an autoantibody or antibody against CNOT7 could matter depends on whether native CNOT7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CNOT7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CNOT7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CNOT7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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