Seroatlas · Human Serome Atlas

ERI3

ERI1 exoribonuclease 3

Also known as: ERI3_HUMAN, FLJ22943, PINT1, PRNPIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43414
Gene: ERI3
Ensembl: ENSG00000117419
Chromosome: 1
Canonical length: 337 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>O43414|ERI3
     1  MATASPAADG GRGRPWEGGL VSWPPAPPLT LPWTWMGPSW GQHPGHWGFP ALTEPSASPA
    61  AGLGIFEVRR VLDASGCSML APLQTGAARF SSYLLSRARK VLGSHLFSPC GVPEFCSIST
   121  RKLAAHGFGA SMAAMVSFPP QRYHYFLVLD FEATCDKPQI HPQEIIEFPI LKLNGRTMEI
   181  ESTFHMYVQP VVHPQLTPFC TELTGIIQAM VDGQPSLQQV LERVDEWMAK EGLLDPNVKS
   241  IFVTCGDWDL KVMLPGQCQY LGLPVADYFK QWINLKKAYS FAMGCWPKNG LLDMNKGLSL
   301  QHIGRPHSGI DDCKNIANIM KTLAYRGFIF KQTSKPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 100 nTPM
amygdala: 93 nTPM
hippocampal formation: 91 nTPM
basal ganglia: 90 nTPM
testis: 85 nTPM
choroid plexus: 79 nTPM

Single-cell type

late spermatids: 1,634 nCPM
early spermatids: 241 nCPM
choroid plexus epithelial cells: 234 nCPM
proximal tubule cells: 166 nCPM
lactotrophs: 148 nCPM
astrocytes: 145 nCPM

Immune cell

myeloid DC: 40 nTPM
non-classical monocyte: 38 nTPM
intermediate monocyte: 36 nTPM
naive B-cell: 31 nTPM
memory B-cell: 31 nTPM
plasmacytoid DC: 30 nTPM

Brain region

pons: 139 nTPM
cerebral cortex: 113 nTPM
hippocampal formation: 112 nTPM
midbrain: 110 nTPM
thalamus: 104 nTPM
amygdala: 101 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 2.2
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERI3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PRNP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERI3 as an antibody target. Whether an autoantibody or antibody against ERI3 could matter depends on whether native ERI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERI3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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