Seroatlas · Human Serome Atlas

KIAA1586

E3 SUMO-protein ligase KIAA1586

Also known as: K1586_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCI6
Gene: KIAA1586
Ensembl: ENSG00000168116
Chromosome: 6
Canonical length: 787 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

Enables SUMO ligase activity. Involved in protein sumoylation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

787 residues, UniProt reviewed canonical sequence.

>Q9HCI6|KIAA1586
     1  MGDPGSEIIE SVPPAGPEAS ESTTDENEDD IQFVSEGPSR PVLEYIDLVC GDDENPSAYY
    61  SDILFPKMPK RQGDFLHFLN VKKVKTDTEN NEVSKNHCRL SKAKEPHFEY IEQPIIEEKP
   121  SLSSKKEIDN LVLPDCWNEK QAFMFTEQYK WLEIKEGKLG CKDCSAVRHL GSKAEKHVHV
   181  SKEWIAYLVT PNGSNKTTRQ ASLRKKIREH DVSKAHGKIQ DLLKESTNDS ICNLVHKQNN
   241  KNIDATVKVF NTVYSLVKHN RPLSDIEGAR ELQEKNGEVN CLNTRYSATR IAEHIAKEMK
   301  MKIFKNIIEE NAKICIIIDE ASTVSKKTTL VIYLQCTIQS APAPVMLFVA LKELVSTIAE
   361  CIVNTLLTTL NDCGFTNEYL KANLIAFCSD GANTILGRKS GVATKLLENF PEIIIWNCLN
   421  HRLQLSLDDS ISEIKQINHL KIFIDKIYSI YHQPNKNQTK LLGTVAKELE TEIIKIGRVM
   481  GPRWAACSLQ AATAVWHAYP ILYMHFSHSY SGLAKRLANI NFLQDLALMI DILEEFSVLS
   541  TALQSRSTNI KKAQKLIKRT IRALENLKIG TGKYESQIED LIKSDKFKDI PFNKNNKFNA
   601  LPRSILLDNI IQHMNLRLLS DRNHEDIFNY FDLLEPSTWP YEEITSPWIA GEKTLFHLCK
   661  ILKYEVDLND FREFVNNNIK SNNVSIPTTI YKAKKIVSTI AINSAEAERG FNLMNIICTR
   721  VRNSLTIDHV SDLMTINLLG KELADWDATP FVKSWSNCNH RLATDTRVRQ KSTKVFHENQ
   781  LAIWNLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KIAA1586 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 8.9 nTPM

Expression across tissuesHPA

Tissue

placenta: 8.9 nTPM
bone marrow: 8.1 nTPM
testis: 7.5 nTPM
ovary: 7.2 nTPM
cerebral cortex: 5.7 nTPM
endometrium: 5.7 nTPM

Single-cell type

early spermatids: 135 nCPM
erythrocyte progenitors: 80 nCPM
platelets: 72 nCPM
cytotrophoblasts: 58 nCPM
megakaryocyte-erythroid progenitors: 54 nCPM
extravillous trophoblasts: 49 nCPM

Immune cell

NK-cell: 5.4 nTPM
T-reg: 4.4 nTPM
naive CD4 T-cell: 4.2 nTPM
plasmacytoid DC: 4.1 nTPM
myeloid DC: 4 nTPM
memory B-cell: 3.7 nTPM

Brain region

cerebellum: 27 nTPM
cerebral cortex: 15 nTPM
hypothalamus: 14 nTPM
pons: 14 nTPM
white matter: 13 nTPM
midbrain: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KIAA1586.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 116 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Schizophrenia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: -0.54
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein sumoylation

Molecular functions

SUMO ligase activity

Protein domainsUniProt · Pfam · InterPro

Ribonuclease H-like superfamily

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KIAA1586 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SUMO2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KIAA1586 as an antibody target. Whether an autoantibody or antibody against KIAA1586 could matter depends on whether native KIAA1586 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KIAA1586 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KIAA1586 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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