Seroatlas · Human Serome Atlas

ERI2

ERI1 exoribonuclease 2

Also known as: ERI2_HUMAN, EXOD1, KIAA1504, MGC16943, ZGRF5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8K979
Gene: ERI2
Ensembl: ENSG00000196678
Chromosome: 16
Canonical length: 691 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable 3'-5'-RNA exonuclease activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>A8K979|ERI2
     1  MATKRLARQL GLIRRKSIAP ANGNLGRSKS KQLFDYLIVI DFESTCWNDG KHHHSQEIIE
    61  FPAVLLNTST GQIDSEFQAY VQPQEHPILS EFCMELTGIK QAQVDEGVPL KICLSQFCKW
   121  IHKIQQQKNI IFATGISEPS ASEVKLCAFV TWSDWDLGVC LEYECKRKQL LKPVFLNSWI
   181  DLRATYKLFY RRKPKGLSGA LQEVGIEFSG REHSGLDDSR NTALLAWKMI RDGCVMKITR
   241  SLNKVPTKKN FSILARNLNT IQVEEMSACN ISIQGPSIYN KEPKNIINPH EKVQMKSICA
   301  NSPIKAQQDQ LQVKNNIKAS LHNVKSSLPL FNTKSSTSVG QLQSPTLNSP IYMQKQGKNE
   361  HLAFNTKSKA STVGSELVLV STTVPTVHHV SDLEMSSTLD CLPVLADWED VVLLPASQPE
   421  ENVDCTVPIS DSDLEISFNS GERLMVLKEL EMSSHENFGD IEETPQKSET SKSIVYKSPH
   481  TTIYNVKEAK DPGSDISAFK LPEHKSSTFN RVNANMSHPL VLGKHPLLSG GTKRNPCSPQ
   541  AFPPAKKQPF TIHEEKPTSS DCSPVRSSSW RRLPSILTST VNLQEPWKSG KMTPPLCKCG
   601  RRSKRLVVSN NGPNHGKVFY CCPIGKYQEN RKCCGYFKWE QTLQKERANS MVPSHSTGGL
   661  TFSSPETSHI CDRNLSISTK NSLRLRPSMR N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 13 nTPM
testis: 12 nTPM
liver: 11 nTPM
rectum: 9.6 nTPM
breast: 8.6 nTPM
stomach: 8 nTPM

Single-cell type

epicardial cells: 198 nCPM
early primary spermatocytes: 102 nCPM
hepatic stellate cells: 84 nCPM
adipocytes: 80 nCPM
fibroblasts: 66 nCPM
hematopoietic stem cells: 65 nCPM

Immune cell

basophil: 14 nTPM
non-classical monocyte: 2.6 nTPM
myeloid DC: 1.9 nTPM
classical monocyte: 1.8 nTPM
eosinophil: 1.7 nTPM
intermediate monocyte: 1.3 nTPM

Brain region

white matter: 7.4 nTPM
medulla oblongata: 6 nTPM
basal ganglia: 5.9 nTPM
choroid plexus: 5.8 nTPM
thalamus: 5.5 nTPM
spinal cord: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 1.5
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERI2 as an antibody target. Whether an autoantibody or antibody against ERI2 could matter depends on whether native ERI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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