ERVK-8
Endogenous retrovirus group K member 8 Pol protein
Also known as: POK8_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for ERVK-8 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
956 residues, UniProt reviewed canonical sequence.
>P63133|ERVK-8
1 NKSKKRRNRV SFLGVATIEP PKPIPLTWKT EKLVWVNQWP LPKQKLEALH LLANEQLEKG
61 HIEPSFSPWN SPVFVIQKKS GKWRMLTDLR AVNAVIQPMG PLQPGLPSPA MIPKDWPLII
121 IDLKDCFFTI PLAEQDCEKF AFTIPAINNK EPATRFQWKV LPQGMLNSPT ICQTFVGRAL
181 QPVRKKFSDC YIIHYIDDIL CAAETKDKLI DCYTFLQAEV ASAGLAIASD KIQTSTPFHY
241 LGMQIENRKI KPQKIEIRKD TLKTLNDFQK LLGDINWIQP TLGIPTYAMS NLFSILRGDS
301 DLNSKRILTP EATKEIKLVE EKIQSAQINR IDPLAPLQLL IFATAHSPTG IIIQNTDLVE
361 WSFLPHSTVK TFTLYLDQIA TLIGQTRLRI IKLCGNDPDK IVVPLTKEQV RQAFINSGAW
421 QIGLANFVGI IDNHYPKTKI FQFLKLTTWI LPKITRREPL ENALTVFTDG SSNGKAAYTG
481 PKERVIKTPY QSAQRAELVA VITVLQDFDQ PINIISDSAY VVQATRVVET ALIKYSMDDQ
541 LNQLFNLLQQ TVRKRNFPFY ITHIRAHTNL PGPLTKANEQ ADLLVSSALI KAQELHALTH
601 VNAAGLKNKF DVTWKQAKDI VQHCTQCQVL HLPTQEAGVN PRGLCPNALW QMDVTHVPSF
661 GRLSYVHVTV DTYSHFIWAT CQTGESTSHV KKHLLSCFAV MGVPEKIKTD NGPGYCSKAF
721 QKFLSQWKIS HTTGIPYNSQ GQAIVERTNR TLKTQLVKQK EGGDSKECTT PQMQLNLALY
781 TLNFLNIYRN QTTTSAEQHL TGKKNSPHEG KLIWWKDNKN KTWEIGKVIT WGRGFACVSP
841 GENQLPVWIP TRHLKFYNEP IRDAKKSTSA ETETPQSSTV DSQDEQNGDV RRTDEVAIHQ
901 EGRAADLGTT KEADAVSYKI SREHKGDTNP REYAACSLDD CINGGKSPYA CRSSCSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ERVK-8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
OntologyGO
Biological processes
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Reverse transcriptase domain
- Integrase, C-terminal, retroviral
- Integrase, catalytic core
- Ribonuclease H domain
- Integrase, N-terminal zinc-binding domain
- Reverse transcriptase thumb
- Ribonuclease H-like superfamily
- Integrase-like, N-terminal
- Ribonuclease H superfamily
- Integrase, C-terminal domain superfamily, retroviral
- Reverse transcriptase/Diguanylate cyclase domain
- DNA/RNA polymerase superfamily
- RNase H
- Reverse transcriptase (RNA-dependent DNA polymerase)
- Integrase DNA binding domain
- Integrase core domain
- Integrase Zinc binding domain
- Reverse transcriptase thumb domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ERVK-8 as an antibody target. Whether an autoantibody or antibody against ERVK-8 could matter depends on whether native ERVK-8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ERVK-8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ERVK-8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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