EXD3

Protein identityUniProt · HPA

UniProt accession

Q8N9H8

Gene

EXD3

Ensembl

ENSG00000187609

Chromosome

9

Canonical length

876 aa

Protein class

Predicted intracellular proteins

Subcellular location

Actin filaments,Focal adhesion sites

OverviewNCBI Gene

Predicted to enable 3'-5' exonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be involved in nucleobase-containing compound metabolic process. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

876 residues, UniProt reviewed canonical sequence.

>Q8N9H8|EXD3
     1  MDPGDPAGDP AAGERHRMGR DPLLLLQALQ TLWSTRERKQ LREEAWRGFA ALDDPLAGLL
    61  DMLESCRGQR GEGPSLAAWI SHQLQCWLQA QPCPSLAQHS LRLKQLQARA VKVLTESPPS
   121  LAAPLASIFQ LQDADRSCLL AHVHRLHHEG RFREAATLGA TLKLQSELGV EKMSIPLLLQ
   181  DKVALVERYV AGFPDLQRRL LVLMDSWCQP GFDIKDVARR YPEVTSLSLE KLSPKALSRQ
   241  VLRLQERYGV APALCPNAAI QQRLAALRHL CHKRFVEKSL SQENWTDHVQ GLVGQSPWLQ
   301  EQLSQLLVSH SDPVTAAQCA MELLLPEERL PAAVAVELRR FRLQGRATEA DSRLEVKDMK
   361  DRYYQLPIPR ENVHLLASWE DLTRHEGALL QCHQVVGVDV EWTPVFVAGG RPRPSLLQVA
   421  VEGHVFLLDV LALSQPPTGQ GAQAFSRLVA QLLSDPSITK LGYGMVGDLQ KLGTSCPALA
   481  HVEKQILGGM DLLLVHRQMR VASVPAPAVD RARELRGLSL LVQQVLGTAL DKTQQLSNWD
   541  RRPLCEEQVI YAAADAYCLL EVHQALCREP ARFHLSEDLA GSRRPRHRER PGARKPPGLQ
   601  KASAPAAPRQ VPVAVAVSEG AAPQIPARAF RVVCDNMLQG LARSLRCLGV DARMLGNGED
   661  HRRAAEVARQ EGRIILTSGQ PFHKLRAQVG AGRCLSVDCS LKAQQQAKAV LKHFNVRVTH
   721  ADIFSRCQAC NCDQYLKVSR DMMKQLMWLS SHQEGPRSSG DEATQSQAVQ EPGPAPDAAP
   781  EGCTYDRPCR WLQMADLRAE TPDMLADGTR LQLAGVPVGV LRTPGLRCFY CCTGCGKVFW
   841  DGSHLGRVAT HFRDMLESAP SPCEPSPAPS PASSPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

15 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0

gnomAD missense Z

0.04

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• nucleobase-containing compound metabolic process

Molecular functions

• 3'-5' exonuclease activity
• metal ion binding
• nucleic acid binding

Protein domainsUniProt · Pfam · InterPro

• 3'-5' exonuclease domain
• Ribonuclease H-like superfamily
• Ribonuclease H superfamily
• 3'-5' exonuclease
• Mut7-C RNAse domain
• Exonuclease Mut-7, DEDDy 3'-5' exonuclease domain
• Exonuclease MUT-7-like
• Mut7-C RNAse domain

KeywordsUniProt

• Exonuclease
• Hydrolase
• Magnesium
• Metal-binding
• Nuclease