Seroatlas · Human Serome Atlas

THAP12

52 kDa repressor of the inhibitor of the protein kinase

Also known as: DAP4, P52K_HUMAN, P52rIPK, PRKRIR, THAP0

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43422
Gene: THAP12
Ensembl: ENSG00000137492
Chromosome: 11
Canonical length: 761 aa
Protein class: Plasma proteins, Predicted membrane proteins, Transcription factors
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable several functions, including DNA binding activity; protein dimerization activity; and zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation and signal transduction. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

761 residues, UniProt reviewed canonical sequence.

>O43422|THAP12
     1  MPNFCAAPNC TRKSTQSDLA FFRFPRDPAR CQKWVENCRR ADLEDKTPDQ LNKHYRLCAK
    61  HFETSMICRT SPYRTVLRDN AIPTIFDLTS HLNNPHSRHR KRIKELSEDE IRTLKQKKID
   121  ETSEQEQKHK ETNNSNAQNP SEEEGEGQDE DILPLTLEEK ENKEYLKSLF EILILMGKQN
   181  IPLDGHEADE IPEGLFTPDN FQALLECRIN SGEEVLRKRF ETTAVNTLFC SKTQQRQMLE
   241  ICESCIREET LREVRDSHFF SIITDDVVDI AGEEHLPVLV RFVDESHNLR EEFIGFLPYE
   301  ADAEILAVKF HTMITEKWGL NMEYCRGQAY IVSSGFSSKM KVVASRLLEK YPQAIYTLCS
   361  SCALNMWLAK SVPVMGVSVA LGTIEEVCSF FHRSPQLLLE LDNVISVLFQ NSKERGKELK
   421  EICHSQWTGR HDAFEILVEL LQALVLCLDG INSDTNIRWN NYIAGRAFVL CSAVSDFDFI
   481  VTIVVLKNVL SFTRAFGKNL QGQTSDVFFA AGSLTAVLHS LNEVMENIEV YHEFWFEEAT
   541  NLATKLDIQM KLPGKFRRAH QGNLESQLTS ESYYKETLSV PTVEHIIQEL KDIFSEQHLK
   601  ALKCLSLVPS VMGQLKFNTS EEHHADMYRS DLPNPDTLSA ELHCWRIKWK HRGKDIELPS
   661  TIYEALHLPD IKFFPNVYAL LKVLCILPVM KVENERYENG RKRLKAYLRN TLTDQRSSNL
   721  ALLNINFDIK HDLDLMVDTY IKLYTSKSEL PTDNSETVEN T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

tongue: 31 nTPM
thymus: 28 nTPM
lymph node: 27 nTPM
bone marrow: 27 nTPM
skeletal muscle: 26 nTPM
breast: 26 nTPM

Single-cell type

rod photoreceptor cells: 64 nCPM
parietal cells: 57 nCPM
megakaryocyte progenitors: 56 nCPM
differentiating spermatogonia: 53 nCPM
erythrocyte progenitors: 50 nCPM
pancreatic acinar cells: 47 nCPM

Immune cell

NK-cell: 3.9 nTPM
MAIT T-cell: 3.2 nTPM
T-reg: 3.1 nTPM
memory CD8 T-cell: 3 nTPM
naive CD8 T-cell: 2.9 nTPM
gdT-cell: 2.8 nTPM

Brain region

cerebral cortex: 8.4 nTPM
midbrain: 8.3 nTPM
hypothalamus: 8.1 nTPM
medulla oblongata: 7.6 nTPM
pons: 7.6 nTPM
choroid plexus: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.32
gnomAD pLI: 0.97
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

THAP-type zinc finger
HAT, C-terminal dimerisation domain
Ribonuclease H-like superfamily
ZMYM1-like, RNase-like domain
THAP domain
hAT family C-terminal dimerisation region
ZMYM1/FAM200, RNase-like domain
Interferon-induced PKR regulator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THAP12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP12 as an antibody target. Whether an autoantibody or antibody against THAP12 could matter depends on whether native THAP12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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