Seroatlas · Human Serome Atlas

PIWIL3

Piwi-like protein 3

Also known as: HIWI3, PIWL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3Z3
Gene: PIWIL3
Ensembl: ENSG00000184571
Chromosome: 22
Canonical length: 882 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytoplasmic bodies

OverviewNCBI Gene

This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

882 residues, UniProt reviewed canonical sequence.

>Q7Z3Z3|PIWIL3
     1  MPGRARTRAR GRARRRESYQ QEAPGGPRAP GSATTQEPPQ LQSTPRPLQE EVPVVRPLQP
    61  RAARGGAGGG AQSQGVKEPG PEAGLHTAPL QERRIGGVFQ DLVVNTRQDM KHVKDSKTGS
   121  EGTVVQLLAN HFRVISRPQW VAYKYNVDYK PDIEDGNLRT ILLDQHRRKF GERHIFDGNS
   181  LLLSRPLKER RVEWLSTTKD KNIVKITVEF SKELTPTSPD CLRYYNILFR RTFKLLDFEQ
   241  VGRNYYTKKK AIQLYRHGTS LEIWLGYVTS VLQYENSITL CADVSHKLLR IETAYDFIKR
   301  TSAQAQTGNI REEVTNKLIG SIVLTKYNNK TYRVDDIDWK QNPEDTFNKS DGSKITYIDY
   361  YRQQHKEIVT VKKQPLLVSQ GRWKKGLTGT QREPILLIPQ LCHMTGLTDE ICKDYSIVKE
   421  LAKHTRLSPR RRHHTLKEFI NTLQDNKKVR ELLQLWDLKF DTNFLSVPGR VLKNANIVQG
   481  RRMVKANSQG DWSREIRELP LLNAMPLHSW LILYSRSSHR EAMSLKGHLQ SVTAPMGITM
   541  KPAEMIEVDG DANSYIDTLR KYTRPTLQMG MSCLLVFKVI CILPNDDKRR YDSIKRYLCT
   601  KCPIPSQCVV KKTLEKVQAR TIVTKIAQQM NCKMGGALWK VETDVQRTMF VGIDCFHDIV
   661  NRQKSIAGFV ASTNAELTKW YSQCVIQKTG EELVKELEIC LKAALDVWCK NESSMPHSVI
   721  VYRDGVGDGQ LQALLDHEAK KMSTYLKTIS PNNFTLAFIV VKKRINTRFF LKHGSNFQNP
   781  PPGTVIDVEL TRNEWYDFFI VSQSVQDGTV TPTHYNVIYD TIGLSPDTVQ RLTYCLCHMY
   841  YNLPGIIRVP APCHYAHKLA YLVGQSIHQE PNRSLSTRLF YL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIWIL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.7 nTPM

Expression across tissuesHPA

Tissue

testis: 0.7 nTPM
ovary: 0.4 nTPM
lymph node: 0.2 nTPM
tonsil: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

oocytes: 55 nCPM
early spermatids: 40 nCPM
innate lymphoid cells: 37 nCPM
differentiating spermatogonia: 11 nCPM
undifferentiated spermatogonia: 5 nCPM
early primary spermatocytes: 2.9 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM
hypothalamus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
thalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIWIL3 as an antibody target. Whether an autoantibody or antibody against PIWIL3 could matter depends on whether native PIWIL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIWIL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIWIL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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