Seroatlas · Human Serome Atlas

ISG20L2

Interferon-stimulated 20 kDa exonuclease-like 2

Also known as: FLJ12671, I20L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9L3
Gene: ISG20L2
Ensembl: ENSG00000143319
Chromosome: 1
Canonical length: 353 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

353 residues, UniProt reviewed canonical sequence.

>Q9H9L3|ISG20L2
     1  MSTLLLNLDF GEPPPKKALE GNAKHRNFVK KRRLLERRGF LSKKNQPPSK APKLHSEPSK
    61  KGETPTVDGT WKTPSFPKKK TAASSNGSGQ PLDKKAAVSW LTPAPSKKAD SVAAKVDLLG
   121  EFQSALPKIN SHPTRSQKKS SQKKSSKKNH PQKNAPQNST QAHSENKCSG ASQKLPRKMV
   181  AIDCEMVGTG PKGHVSSLAR CSIVNYNGDV LYDEYILPPC HIVDYRTRWS GIRKQHMVNA
   241  TPFKIARGQI LKILTGKIVV GHAIHNDFKA LQYFHPKSLT RDTSHIPPLN RKADCPENAT
   301  MSLKHLTKKL LNRDIQVGKS GHSSVEDAQA TMELYKLVEV EWEEHLARNP PTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ISG20L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

testis: 59 nTPM
esophagus: 17 nTPM
bone marrow: 16 nTPM
tonsil: 16 nTPM
urinary bladder: 14 nTPM
lymph node: 14 nTPM

Single-cell type

late spermatids: 5,172 nCPM
early spermatids: 1,011 nCPM
late primary spermatocytes: 171 nCPM
granulosa cells: 58 nCPM
neutrophils: 58 nCPM
suprabasal keratinocytes: 49 nCPM

Immune cell

basophil: 28 nTPM
eosinophil: 17 nTPM
neutrophil: 15 nTPM
non-classical monocyte: 12 nTPM
NK-cell: 12 nTPM
intermediate monocyte: 11 nTPM

Brain region

cerebellum: 16 nTPM
cerebral cortex: 15 nTPM
hippocampal formation: 13 nTPM
hypothalamus: 11 nTPM
medulla oblongata: 11 nTPM
thalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.71
gnomAD pLI: 0.09
gnomAD missense Z: 0.81
DepMap mean gene effect: -0.98
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ISG20L2 as an antibody target. Whether an autoantibody or antibody against ISG20L2 could matter depends on whether native ISG20L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ISG20L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ISG20L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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