Seroatlas · Human Serome Atlas

REXO2

Oligoribonuclease, mitochondrial

Also known as: CGI-114, DKFZP566E144, ORN_HUMAN, SFN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3B8
Gene: REXO2
Ensembl: ENSG00000076043
Chromosome: 11
Canonical length: 237 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Focal adhesion sites,Mitochondria
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

237 residues, UniProt reviewed canonical sequence.

>Q9Y3B8|REXO2
     1  MLGGSLGSRL LRGVGGSHGR FGARGVREGG AAMAAGESMA QRMVWVDLEM TGLDIEKDQI
    61  IEMACLITDS DLNILAEGPN LIIKQPDELL DSMSDWCKEH HGKSGLTKAV KESTITLQQA
   121  EYEFLSFVRQ QTPPGLCPLA GNSVHEDKKF LDKYMPQFMK HLHYRIIDVS TVKELCRRWY
   181  PEEYEFAPKK AASHRALDDI SESIKELQFY RNNIFKKKID EKKRKIIENG ENEKTVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REXO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 145 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 145 nTPM
heart muscle: 135 nTPM
salivary gland: 109 nTPM
smooth muscle: 100 nTPM
kidney: 96 nTPM
blood vessel: 94 nTPM

Single-cell type

esophageal apical cells: 1,142 nCPM
oocytes: 1,068 nCPM
parietal cells: 573 nCPM
decidual stromal cells: 494 nCPM
late primary spermatocytes: 378 nCPM
syncytiotrophoblasts: 374 nCPM

Immune cell

T-reg: 76 nTPM
plasmacytoid DC: 70 nTPM
basophil: 64 nTPM
memory CD4 T-cell: 48 nTPM
NK-cell: 45 nTPM
naive CD4 T-cell: 43 nTPM

Brain region

medulla oblongata: 32 nTPM
hypothalamus: 30 nTPM
pons: 30 nTPM
white matter: 29 nTPM
choroid plexus: 28 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.02
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REXO2 as an antibody target. Whether an autoantibody or antibody against REXO2 could matter depends on whether native REXO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REXO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REXO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...