Seroatlas · Human Serome Atlas

KRBA2

KRAB-A domain-containing protein 2

Also known as: KRBA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNG9
Gene: KRBA2
Ensembl: ENSG00000184619
Chromosome: 17
Canonical length: 492 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA integration and regulation of DNA-templated transcription. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q6ZNG9|KRBA2
     1  MPSFLVPSLV SSPVLLKLLF SPGPKTIWSL WQQPMLFQEA TAFENMTKDW NYLEGSQKDC
    61  YRDTMLDSYE NTVPQGSFLQ LSMMPQRAGN DPPGVSNASE MEMEISNMRE KFLMSVTKLV
   121  ESKSYNSKVF SKEKYFQTIK EVKEAKEKGK KSSRDYRRAA KYDVISVQGT EKLIEATHGE
   181  RDRIRYYVHK EELFDILHDT HLSIGHGGRT RMLKELQGKY GNVTKEVIVL YLTLCKQCHQ
   241  KNPVPKRGLA PKPMTFKDID STCQVEILDM QSSADGEFKF ILYYQDHSTK FIILRPLRTK
   301  QAHEVVSVLL DIFTILGTPS VLDSDSGVEF TNQVVHELNE LWPDLKIVSG KYHPGQSQGS
   361  LEGASRDVKN MISTWMQSNH SCHWAKGLRF MQMVRNQAFD VSLQQSPFEA MFGYKAKFGL
   421  YSSNLPRETV ATLQTEEELE IAEEQLENSL WIRQEERAEI GADRSDMDDD MDPTPEASEP
   481  STSQGTSGLL CW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRBA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

retina: 32 nTPM
heart muscle: 6.4 nTPM
tongue: 6.3 nTPM
skeletal muscle: 5.7 nTPM
parathyroid gland: 3.7 nTPM
cerebellum: 3.6 nTPM

Single-cell type

rod photoreceptor cells: 53 nCPM
choroid plexus epithelial cells: 35 nCPM
astrocytes: 33 nCPM
bergmann glia: 30 nCPM
myonuclei: 23 nCPM
oligodendrocytes: 23 nCPM

Immune cell

basophil: 10 nTPM
naive CD4 T-cell: 3.5 nTPM
naive B-cell: 2.9 nTPM
non-classical monocyte: 2.7 nTPM
eosinophil: 2.3 nTPM
T-reg: 2.2 nTPM

Brain region

white matter: 20 nTPM
cerebellum: 18 nTPM
basal ganglia: 17 nTPM
cerebral cortex: 16 nTPM
thalamus: 15 nTPM
medulla oblongata: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: 0.01
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

nucleic acid binding

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRBA2 as an antibody target. Whether an autoantibody or antibody against KRBA2 could matter depends on whether native KRBA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRBA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRBA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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