Seroatlas · Human Serome Atlas

ERVK-7

Endogenous retrovirus group K member 7 Pol protein

Also known as: POK7_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P63135
Gene: ERVK-7
Canonical length: 1459 aa

OverviewNCBI Gene

No narrative summary is available for ERVK-7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1459 residues, UniProt reviewed canonical sequence.

>P63135|ERVK-7
     1  NKSRKRRNRL SFLGAATVEP PKPIPLTWKT EKPVWVNQWP LPKQKLEALH LLANEQLEKG
    61  HIEPSFSPWN SPVFVIQKKS GKWRMLTDLR AVNAVIQPMG PLQPGLPSPA MIPKDWPLII
   121  IDLKDCFFTI PLAEQDCEKF AFTIPAINNK EPATRFQWKV LPQGMLNSPT ICQTFVGRAL
   181  QPVREKFSDC YIIHYIDDIL CAAETRDKLI DCYTFLQAEV ANAGLAIASD KIQTSTPFHY
   241  LGMQIENRKI KQQKIEIRKD TLKTLNDFQK LLGDINWIRP TLGIPTYAMS NLFSILRGDS
   301  DLNSKRILTP EATKEIKLVE EKIQSAQINR IDPLAPLQLL IFATAHSPTG IIIQNTDLVE
   361  WSFLPHSTVK TFTLYLDQIA TLIGQTRLRI IKLCGNDPDK IVVPLTKEQV RQAFINSGAW
   421  QIGLANFVGI IDNHYPKTKI FQFLKLTTWI LPKITRREPL ENALTVFTDG SSNGKAAYTG
   481  PKERVIKTPY QSAQRAELVA VITVLQDFDQ PINIISDSAY VVQATRDVET ALIKYSMDDQ
   541  LNQLFNLLQQ TVRKRNFPFY ITHIRAHTNL PGPLTKANEQ ADLLVSSALI KAQELHALTH
   601  VNAAGLKNKF DVTWKQAKDI VQHCTQCQIL HLPTQEAGVN PRGLCPNALW QMDVTHVPSF
   661  GRLSYVHVTV DTYSHFIWAT CQTGESTSHV KKHLLSCFAV MGVPEKIKTD NGPGYCSKAF
   721  QKFLSQWKIS HTTGIPYNSQ GQAIVERTNR TLKTQLVKQK EGGDSKECTT PQMQLNLALY
   781  TLNFLNIYRN QTTTSAEQHL TGKKNSPHEG KLIWWKDNKN KTWEIGKVIT WGRGFACVSP
   841  GENQLPVWIP TRHLKFYNEP IGDAKKRAST EMVTPVTWMD NPIEIYVNDS VWVPGPIDDR
   901  CPAKPEEEGM MINISIGYRY PPICLGRAPG CLMPAVQNWL VEVPTVSPIS RFTYHMVSGM
   961  SLRPRVNYLQ DFSYQRSLKF RPKGKPCPKE IPKESKNTEV LVWEECVANS AVILQNNEFG
  1021  TIIDWAPRGQ FYHNCSGQTQ SCPSAQVSPA VDSDLTESLD KHKHKKLQSF YPWEWGEKGI
  1081  STPRPKIVSP VSGPEHPELW RLTVASHHIR IWSGNQTLET RDCKPFYTID LNSSLTVPLQ
  1141  SCVKPPYMLV VGNIVIKPDS QTITCENCRL LTCIDSTFNW QHRILLVRAR EGVWIPVSMD
  1201  RPWEASPSVH ILTEVLKGVL NRSKRFIFTL IAVIMGLIAV TATAAVAGVA LHSSVQSVNF
  1261  VNDWQKNSTR LWNSQSSIDQ KLANQINDLR QTVIWMGDRL MSLEHRFQLQ CDWNTSDFCI
  1321  TPQIYNESEH HWDMVRRHLQ GREDNLTLDI SKLKEQIFEA SKAHLNLVPG TEAIAGVADG
  1381  LANLNPVTWV KTIGSTTIIN LILILVCLFC LLLVCRCTQQ LRRDSDHRER AMMTMAVLSK
  1441  RKGGNVGKSK RDQIVTVSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERVK-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERVK-7 as an antibody target. Whether an autoantibody or antibody against ERVK-7 could matter depends on whether native ERVK-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERVK-7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERVK-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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