ERVK-19
Endogenous retrovirus group K member 19 Pol protein
Also known as: POK19_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for ERVK-19 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
959 residues, UniProt reviewed canonical sequence.
>Q9WJR5|ERVK-19
1 NKSKKRRNRV SFLGAATVEP PKPIPLTWKT EKPVWVNQWP LPKQKLEALH LLANEQLEKG
61 HIEPSFSPWN SPVFVIQKKS GKWRMLTDLR AVNAVNAVIQ PMGPLQPGLP SLAMIPKDWP
121 LIIIDLKDCF FTIPLAEQDC EKFAFTIPAI NNKEPATRFQ WKVLPQGMLN SPTICQTFVG
181 RALQPVREKF SDCYIIHYID DILCAAEMKD KLIDCYTFLQ AEVANAGLAI ASDKIQTSTP
241 FHYLEMQIEN RKIKPPKIEI RKDTLKTLND FQKLLGDINW IRPTLGIPTY AMSNLFSILR
301 GDSDLNSKRM LTPEATKEIK LVEEKIQSAQ INRIDPLAPL QLLIFATAHS PTGIIIQNTD
361 LVEWSFLPHS TVKTFTLYLD QMATLIGQTR LRIIKLCGND PDKIVVPLTK EQVRQAFINS
421 GAWQIGLANF VGIIDNHYPK TKIFQFLKMT TWILPKITRR EPLENALTVF TDGSSNGKAA
481 YTGPKERVIK TQYQSAQRAE LVAVITVLQD FDQPINIISD SAYVVQATRD VETALIKYSM
541 DDQLNQLFNL LQQTVRKRNF PFYITHIRAH TNLPGPLTKA NEQADLLVSS ALIKAQELHA
601 LTHVNVAGLK NKFDVTWKQA KDIVQHCTQC QVLHLPTQEA GVNPRGLCPN ALWQMDVTHV
661 SSFGRLSYIH VTVDTYSHFI WATCQTGEST SHVKKHLLSC FAVMGVPEKI KTDNGPGYCS
721 KAFQKFLSQW KISHTTGIPY NSQGQAIVER TNRTLKTQLV KQKEGGDSKE CTTPQMQLNL
781 ALYTLNFLNI YRNQTTTSAE QHLTGKKNSP HEGKLIWWKD NKNKTWEIGK VITWGRGFAC
841 VSPGENQLPV WIPTRHLKFY NEPIGDAKKS TSAETETPQS STVDSQDEQN GDVRRTDEVA
901 IHQESRAADL GTTKEADAVS YKISREHKGD TNPREYAACG LDDCINGGKS PYACRSSCSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ERVK-19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
OntologyGO
Biological processes
- DNA integration
- DNA recombination
- DNA synthesis involved in DNA repair
- DNA-templated DNA replication
- viral translational frameshifting
Molecular functions
Protein domainsUniProt · Pfam · InterPro
- Reverse transcriptase domain
- Integrase, C-terminal, retroviral
- Integrase, catalytic core
- Ribonuclease H domain
- Integrase, N-terminal zinc-binding domain
- Reverse transcriptase thumb
- Ribonuclease H-like superfamily
- Integrase-like, N-terminal
- Ribonuclease H superfamily
- Integrase, C-terminal domain superfamily, retroviral
- Reverse transcriptase/Diguanylate cyclase domain
- DNA/RNA polymerase superfamily
- RNase H
- Reverse transcriptase (RNA-dependent DNA polymerase)
- Integrase DNA binding domain
- Integrase core domain
- Integrase Zinc binding domain
- Reverse transcriptase thumb domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ERVK-19 as an antibody target. Whether an autoantibody or antibody against ERVK-19 could matter depends on whether native ERVK-19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ERVK-19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ERVK-19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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