ATPase, nucleotide binding domain
IPR043129
Definition
This superfamily comprises domains found in several ATPases, including actin, Hsp70, BadF/BadG/BcrA/BcrD, various kinases, DnaK, ROK, PilM, and Fumble. Members of this superfamily have two lobes, one with nucleotide binding activity, and a second one with substrate binding activity. The lobes can be structurally divided into 4 subdomains - 1A, 1B, 2A, 2B (or 1, 2, 3, 4). The ATP binding site in these ATPases is well conserved, and is located at the junction of the two lobes, in a deep cleft. This superfamily entry represents the nucleotide binding domain (NBD) or the first lobe (subdomains 1A and 1B), which exhibits ATPase activity.
69 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (69 proteins: gene, accession, name)
- ACTA1
- ACTA2
- ACTB
- ACTBL2
- ACTC1
- ACTG1
- ACTG2
- ACTL10
- ACTL6A
- ACTL6B
- ACTL7A
- ACTL7B
- ACTL8
- ACTL9
- ACTR10
- ACTR1A
- ACTR1B
- ACTR2
- ACTR3
- ACTR3B
- ACTR3C
- ACTR5
- ACTR6
- ACTR8
- ACTRT1
- ACTRT2
- ACTRT3
- FGGY
- GCK
- GK
- GK2
- GK3
- GK5
- GNE
- HK1
- HK2
- HK3
- HKDC1
- HSPA12A
- HSPA12B
- HSPA13
- HSPA14
- HSPA1A
- HSPA1B
- HSPA1L
- HSPA2
- HSPA4
- HSPA4L
- HSPA5
- HSPA6
- HSPA7
- HSPA8
- HSPA9
- HSPH1
- HYOU1
- NAGK
- OSGEP
- OSGEPL1
- PANK1
- PANK2
- PANK3
- PANK4
- POTEE
- POTEF
- POTEI
- POTEJ
- POTEKP
- SHPK
- XYLB
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