Seroatlas · Human Serome Atlas

HSPA1A

Heat shock 70 kDa protein 1A

Also known as: HS71A_HUMAN, HSP70-1, HSPA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMV8
Gene
HSPA1A
Ensembl
ENSG00000204389
Chromosome
6
Canonical length
641 aa
Protein class
Disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles,Perinuclear theca,Calyx,Flagellar centriole,Annulus
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

641 residues, UniProt reviewed canonical sequence.

>P0DMV8|HSPA1A
     1  MAKAAAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA
    61  LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFQVINDGDK PKVQVSYKGE TKAFYPEEIS
   121  SMVLTKMKEI AEAYLGYPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA
   181  IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH
   241  FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA
   301  RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN
   361  KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI
   421  PTKQTQIFTT YSDNQPGVLI QVYEGERAMT KDNNLLGRFE LSGIPPAPRG VPQIEVTFDI
   481  DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN
   541  ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE
   601  QVCNPIISGL YQGAGGPGPG GFGAQGPKGG SGSGPTIEEV D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
1,155 nTPM

Expression across tissuesHPA

Tissue

  • liver: 1,155 nTPM
  • lung: 1,054 nTPM
  • cerebellum: 1,051 nTPM
  • heart muscle: 935 nTPM
  • spinal cord: 799 nTPM
  • kidney: 742 nTPM

Single-cell type

  • microglia: 1,396 nCPM
  • astrocytes: 396 nCPM
  • ependymal cells: 350 nCPM
  • oligodendrocytes: 190 nCPM
  • bergmann glia: 177 nCPM
  • podocytes: 69 nCPM

Immune cell

  • neutrophil: 6.9 nTPM
  • intermediate monocyte: 3.6 nTPM
  • eosinophil: 3.2 nTPM
  • T-reg: 3.1 nTPM
  • basophil: 2.3 nTPM
  • classical monocyte: 2.3 nTPM

Brain region

  • medulla oblongata: 5.8 nTPM
  • cerebellum: 5.7 nTPM
  • white matter: 5.7 nTPM
  • midbrain: 3.8 nTPM
  • cerebral cortex: 2.5 nTPM
  • hippocampal formation: 2.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSPA1A.

Disease | ImmuneIEDB

Conditions an epitope on HSPA1A was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0.03
gnomAD missense Z
1.43

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPA1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA1A as an antibody target. Whether an autoantibody or antibody against HSPA1A could matter depends on whether native HSPA1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA1A is annotated as secreted, so native HSPA1A circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HSPA1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSPA1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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