FGGY

Protein identityUniProt · HPA

UniProt accession

Q96C11

Gene

FGGY

Ensembl

ENSG00000172456

Chromosome

1

Canonical length

551 aa

Protein class

Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

This gene encodes a protein that phosphorylates carbohydrates such as ribulose, ribitol, and L-arabinitol. Genome-wide association studies in some populations have found an association between polymorphisms in this gene and sporadic amyotrophic lateral sclerosis, but studies of other populations have not been able to replicate this association. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>Q96C11|FGGY
     1  MSGGEQKPER YYVGVDVGTG SVRAALVDQS GVLLAFADQP IKNWEPQFNH HEQSSEDIWA
    61  ACCVVTKKVV QGIDLNQIRG LGFDATCSLV VLDKQFHPLP VNQEGDSHRN VIMWLDHRAV
   121  SQVNRINETK HSVLQYVGGV MSVEMQAPKL LWLKENLREI CWDKAGHFFD LPDFLSWKAT
   181  GVTARSLCSL VCKWTYSAEK GWDDSFWKMI GLEDFVADNY SKIGNQVLPP GASLGNGLTP
   241  EAARDLGLLP GIAVAASLID AHAGGLGVIG ADVRGHGLIC EGQPVTSRLA VICGTSSCHM
   301  GISKDPIFVP GVWGPYFSAM VPGFWLNEGG QSVTGKLIDH MVQGHAAFPE LQVKATARCQ
   361  SIYAYLNSHL DLIKKAQPVG FLTVDLHVWP DFHGNRSPLA DLTLKGMVTG LKLSQDLDDL
   421  AILYLATVQA IALGTRFIIE AMEAAGHSIS TLFLCGGLSK NPLFVQMHAD ITGMPVVLSQ
   481  EVESVLVGAA VLGACASGDF ASVQEAMAKM SKVGKVVFPR LQDKKYYDKK YQVFLKLVEH
   541  QKEYLAIMND D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGGY can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

71 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGGY.

Disease | AllUniProt

Conditions FGGY is implicated in, by any mechanism.

• Amyotrophic lateral sclerosis (ALS) MIM:105400

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

-0.12

DepMap mean gene effect

0.19

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carbohydrate phosphorylation
• neuron cellular homeostasis
• pentose metabolic process

Molecular functions

• D-ribulokinase activity

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Carbohydrate kinase, FGGY
• Carbohydrate kinase FGGY, N-terminal
• Carbohydrate kinase FGGY, C-terminal
• ATPase, nucleotide binding domain
• FGGY family of carbohydrate kinases, N-terminal domain
• FGGY family of carbohydrate kinases, C-terminal domain
• FGGY carbohydrate kinase, pentulose kinase

KeywordsUniProt

• Amyotrophic lateral sclerosis
• Kinase
• Neurodegeneration
• Transferase