Seroatlas · Human Serome Atlas

GK3

Glycerol kinase 3

Also known as: GK3P, GKP3, GKTB, GLPK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14409
Gene: GK3
Ensembl: ENSG00000229894
Chromosome: 4
Canonical length: 553 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable glycerol kinase activity. Predicted to be involved in glycerol metabolic process; glycerol-3-phosphate biosynthetic process; and triglyceride metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q14409|GK3
     1  MAASKKAVLG PLVGAVDQGT SSTRFLVFNS RTAELLSHHQ VEIKQEFPRE GWVEQDPKEI
    61  LHSVYECIEK TCEKLGQLNI GISNIKAIGV SNQRETTVVW DKITGEPLYN AVVWLDLRTQ
   121  STVESLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VRKVQKAVEE KRALFGTIDS
   181  WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PHVRSSSEIY
   241  GLMKAGALEG VPISGCLGDQ SAALVGQMCF QIGQAKNTYG TGCFLLCNTG HKCVFSDHGL
   301  LTTVAYKLGR DKPVYYALEG SVAIAGAVIR WLRDNLGIIK TSEEIEKLAK EVGTSYGCYF
   361  VPAFSGLYAP YWEPSARGII CGLTQFTNKC HIAFAALEAV CFQTREILDA MNRDCGIPLS
   421  HLQVDGGMTS NKILMQLQAD ILYIPVVKPL MPETTALGAA MAAGAAEGVD VWSLEPEDLS
   481  AVTMERFEPQ INAEESEIRY STWKKAVMKS MGWVTTQSPE GGDPSVFCSL PLGFFIVSSM
   541  AMLIGARYIS GIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
bone marrow: 0.4 nTPM
liver: 0.1 nTPM
lung: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

early spermatids: 80 nCPM
late primary spermatocytes: 75 nCPM
late spermatids: 35 nCPM
podocytes: 3.1 nCPM
proximal tubule cells: 3.1 nCPM
renal collecting duct intercalated cells: 2.9 nCPM

Immune cell

neutrophil: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hippocampal formation: 8.1 nTPM
cerebral cortex: 6.8 nTPM
white matter: 6.5 nTPM
basal ganglia: 6.3 nTPM
thalamus: 5.1 nTPM
medulla oblongata: 4.7 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GK3 as an antibody target. Whether an autoantibody or antibody against GK3 could matter depends on whether native GK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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