Seroatlas · Human Serome Atlas

ACTRT3

Actin-related protein T3

Also known as: ACTT3_HUMAN, ARPM1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYD9
Gene: ACTRT3
Ensembl: ENSG00000184378
Chromosome: 3
Canonical length: 372 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol,Acrosome

OverviewNCBI Gene

Predicted to be located in cytoplasm; cytoskeleton; and male germ cell nucleus. Predicted to be active in actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q9BYD9|ACTRT3
     1  MNHCQLPVVI DNGSGMIKAG VAGCREPQFI YPNIIGRAKG QSRAAQGGLE LCVGDQAQDW
    61  RSSLFISYPV ERGLITSWED MEIMWKHIYD YNLKLKPCDG PVLITEPALN PLANRQQITE
   121  MFFEHLGVPA FYMSIQAVLA LFAAGFTTGL VLNSGAGVTQ SVPIFEGYCL PHGVQQLDLA
   181  GLDLTNYLMV LMKNHGIMLL SASDRKIVED IKESFCYVAM NYEEEMAKKP DCLEKVYQLP
   241  DGKVIQLHDQ LFSCPEALFS PCHMNLEAPG IDKICFSSIM KCDTGLRNSF FSNIILAGGS
   301  TSFPGLDKRL VKDIAKVAPA NTAVQVIAPP ERKISVWMGG SILASLSAFQ DMWITAAEFK
   361  EVGPNIVHQR CF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTRT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

testis: 54 nTPM
liver: 2.9 nTPM
choroid plexus: 2.3 nTPM
kidney: 2.3 nTPM
fallopian tube: 1.9 nTPM
seminal vesicle: 1.8 nTPM

Single-cell type

early spermatids: 1,180 nCPM
late primary spermatocytes: 534 nCPM
late spermatids: 159 nCPM
cardiomyocytes: 16 nCPM
megakaryocytes: 12 nCPM
retinal pigment epithelial cells: 8.5 nCPM

Immune cell

MAIT T-cell: 0.9 nTPM
memory B-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive B-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

cerebral cortex: 7.3 nTPM
midbrain: 5.8 nTPM
cerebellum: 4.3 nTPM
thalamus: 3.8 nTPM
white matter: 3.8 nTPM
medulla oblongata: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: 0.22
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTRT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PFN3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTRT3 as an antibody target. Whether an autoantibody or antibody against ACTRT3 could matter depends on whether native ACTRT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTRT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTRT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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