Seroatlas · Human Serome Atlas

HSPA8

Heat shock cognate 71 kDa protein

Also known as: HSC70, HSC71, HSP73, HSP7C_HUMAN, HSPA10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P11142
Gene
HSPA8
Ensembl
ENSG00000109971
Chromosome
11
Canonical length
646 aa
Protein class
Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Perinuclear theca,Calyx,Flagellar centriole,Annulus
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

646 residues, UniProt reviewed canonical sequence.

>P11142|HSPA8
     1  MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA
    61  MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS
   121  SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA
   181  IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH
   241  FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA
   301  RFEELNADLF RGTLDPVEKA LRDAKLDKSQ IHDIVLVGGS TRIPKIQKLL QDFFNGKELN
   361  KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI
   421  PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI
   481  DANGILNVSA VDKSTGKENK ITITNDKGRL SKEDIERMVQ EAEKYKAEDE KQRDKVSSKN
   541  SLESYAFNMK ATVEDEKLQG KINDEDKQKI LDKCNEIINW LDKNQTAEKE EFEHQQKELE
   601  KVCNPIITKL YQSAGGMPGG MPGGFPGGGA PPSGGASSGP TIEEVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
1,423 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 1,423 nTPM
  • tongue: 1,408 nTPM
  • pancreas: 1,146 nTPM
  • tonsil: 824 nTPM
  • urinary bladder: 808 nTPM
  • heart muscle: 802 nTPM

Single-cell type

  • syncytiotrophoblasts: 1,640 nCPM
  • breast lactating cells: 1,372 nCPM
  • epididymal principal cells: 1,372 nCPM
  • migrating cytotrophoblasts: 1,055 nCPM
  • pancreatic duct cells: 1,047 nCPM
  • extravillous trophoblasts: 1,033 nCPM

Immune cell

  • total PBMC: 3,437 nTPM
  • T-reg: 1,766 nTPM
  • MAIT T-cell: 1,502 nTPM
  • memory CD4 T-cell: 1,446 nTPM
  • naive CD4 T-cell: 1,371 nTPM
  • memory CD8 T-cell: 1,366 nTPM

Brain region

  • white matter: 1,044 nTPM
  • pons: 1,019 nTPM
  • hypothalamus: 999 nTPM
  • cerebellum: 943 nTPM
  • choroid plexus: 907 nTPM
  • midbrain: 904 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSPA8.

Disease | ImmuneIEDB

Conditions an epitope on HSPA8 was assayed in.

Disease | AutoantibodyPubMed

Conditions in which antibodies against HSPA8 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for HSPA8 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

13 publications

Show 8 more

Reference: B cellIEDB

1 publication

Reference: T cellIEDB

3 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
4.46
DepMap mean gene effect
-0.85
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPA8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA8 as an antibody target. Whether an autoantibody or antibody against HSPA8 could matter depends on whether native HSPA8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA8 is annotated at the cell surface, where native HSPA8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HSPA8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSPA8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...