Seroatlas · Human Serome Atlas

HK3

Hexokinase-3

Also known as: HXK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P52790
Gene: HK3
Ensembl: ENSG00000160883
Chromosome: 5
Canonical length: 923 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

923 residues, UniProt reviewed canonical sequence.

>P52790|HK3
     1  MDSIGSSGLR QGEETLSCSE EGLPGPSDSS ELVQECLQQF KVTRAQLQQI QASLLGSMEQ
    61  ALRGQASPAP AVRMLPTYVG STPHGTEQGD FVVLELGATG ASLRVLWVTL TGIEGHRVEP
   121  RSQEFVIPQE VMLGAGQQLF DFAAHCLSEF LDAQPVNKQG LQLGFSFSFP CHQTGLDRST
   181  LISWTKGFRC SGVEGQDVVQ LLRDAIRRQG AYNIDVVAVV NDTVGTMMGC EPGVRPCEVG
   241  LVVDTGTNAC YMEEARHVAV LDEDRGRVCV SVEWGSFSDD GALGPVLTTF DHTLDHESLN
   301  PGAQRFEKMI GGLYLGELVR LVLAHLARCG VLFGGCTSPA LLSQGSILLE HVAEMEDPST
   361  GAARVHAILQ DLGLSPGASD VELVQHVCAA VCTRAAQLCA AALAAVLSCL QHSREQQTLQ
   421  VAVATGGRVC ERHPRFCSVL QGTVMLLAPE CDVSLIPSVD GGGRGVAMVT AVAARLAAHR
   481  RLLEETLAPF RLNHDQLAAV QAQMRKAMAK GLRGEASSLR MLPTFVRATP DGSERGDFLA
   541  LDLGGTNFRV LLVRVTTGVQ ITSEIYSIPE TVAQGSGQQL FDHIVDCIVD FQQKQGLSGQ
   601  SLPLGFTFSF PCRQLGLDQG ILLNWTKGFK ASDCEGQDVV SLLREAITRR QAVELNVVAI
   661  VNDTVGTMMS CGYEDPRCEI GLIVGTGTNA CYMEELRNVA GVPGDSGRMC INMEWGAFGD
   721  DGSLAMLSTR FDASVDQASI NPGKQRFEKM ISGMYLGEIV RHILLHLTSL GVLFRGQQIQ
   781  RLQTRDIFKT KFLSEIESDS LALRQVRAIL EDLGLPLTSD DALMVLEVCQ AVSQRAAQLC
   841  GAGVAAVVEK IRENRGLEEL AVSVGVDGTL YKLHPRFSSL VAATVRELAP RCVVTFLQSE
   901  DGSGKGAALV TAVACRLAQL TRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 122 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 122 nTPM
spleen: 73 nTPM
lung: 24 nTPM
appendix: 18 nTPM
adipose tissue: 7.8 nTPM
smooth muscle: 7.4 nTPM

Single-cell type

neutrophils: 120 nCPM
neutrophil progenitors: 103 nCPM
kupffer cells: 82 nCPM
monocytes: 56 nCPM
hofbauer cells: 36 nCPM
monocyte progenitors: 23 nCPM

Immune cell

basophil: 571 nTPM
eosinophil: 205 nTPM
non-classical monocyte: 201 nTPM
intermediate monocyte: 179 nTPM
classical monocyte: 93 nTPM
total PBMC: 44 nTPM

Brain region

cerebellum: 8.6 nTPM
thalamus: 8.1 nTPM
cerebral cortex: 7.2 nTPM
choroid plexus: 4.8 nTPM
hippocampal formation: 4.2 nTPM
amygdala: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.03
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HK3 as an antibody target. Whether an autoantibody or antibody against HK3 could matter depends on whether native HK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HK3 is annotated as secreted, so native HK3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label HK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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