Seroatlas · Human Serome Atlas

HSPA14

Heat shock 70 kDa protein 14

Also known as: HSP70-4, HSP70L1, HSP7E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0VDF9
Gene: HSPA14
Ensembl: ENSG00000187522
Chromosome: 10
Canonical length: 509 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein refolding. Located in cytosol and ribosome. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

509 residues, UniProt reviewed canonical sequence.

>Q0VDF9|HSPA14
     1  MAAIGVHLGC TSACVAVYKD GRAGVVANDA GDRVTPAVVA YSENEEIVGL AAKQSRIRNI
    61  SNTVMKVKQI LGRSSSDPQA QKYIAESKCL VIEKNGKLRY EIDTGEETKF VNPEDVARLI
   121  FSKMKETAHS VLGSDANDVV ITVPFDFGEK QKNALGEAAR AAGFNVLRLI HEPSAALLAY
   181  GIGQDSPTGK SNILVFKLGG TSLSLSVMEV NSGIYRVLST NTDDNIGGAH FTETLAQYLA
   241  SEFQRSFKHD VRGNARAMMK LTNSAEVAKH SLSTLGSANC FLDSLYEGQD FDCNVSRARF
   301  ELLCSPLFNK CIEAIRGLLD QNGFTADDIN KVVLCGGSSR IPKLQQLIKD LFPAVELLNS
   361  IPPDEVIPIG AAIEAGILIG KENLLVEDSL MIECSARDIL VKGVDESGAS RFTVLFPSGT
   421  PLPARRQHTL QAPGSISSVC LELYESDGKN SAKEETKFAQ VVLQDLDKKE NGLRDILAVL
   481  TMKRDGSLHV TCTDQETGKC EAISIEIAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 40 nTPM
testis: 29 nTPM
skeletal muscle: 22 nTPM
lymph node: 18 nTPM
tonsil: 18 nTPM
thymus: 17 nTPM

Single-cell type

early primary spermatocytes: 179 nCPM
late primary spermatocytes: 134 nCPM
extravillous trophoblasts: 67 nCPM
differentiating spermatogonia: 44 nCPM
syncytiotrophoblasts: 43 nCPM
migrating cytotrophoblasts: 41 nCPM

Immune cell

T-reg: 20 nTPM
intermediate monocyte: 18 nTPM
NK-cell: 18 nTPM
memory CD8 T-cell: 17 nTPM
non-classical monocyte: 16 nTPM
basophil: 16 nTPM

Brain region

cerebellum: 21 nTPM
cerebral cortex: 15 nTPM
white matter: 14 nTPM
hippocampal formation: 13 nTPM
hypothalamus: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.67
gnomAD missense Z: 1.17
DepMap mean gene effect: -0.29
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Heat shock protein 70 family
Heat shock protein 70, conserved site
Heat shock protein 70kD, peptide-binding domain superfamily
ATPase, nucleotide binding domain
Hsp70 protein
Heat shock 70kDa protein 14, nucleotide-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPA14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA14 as an antibody target. Whether an autoantibody or antibody against HSPA14 could matter depends on whether native HSPA14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPA14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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