Seroatlas · Human Serome Atlas

HSPA12A

Heat shock 70 kDa protein 12A

Also known as: FLJ13874, HS12A_HUMAN, KIAA0417

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43301
Gene: HSPA12A
Ensembl: ENSG00000165868
Chromosome: 10
Canonical length: 675 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable ATP binding activity. Predicted to act upstream of or within several processes, including import into nucleus; liver development; and macrophage activation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

675 residues, UniProt reviewed canonical sequence.

>O43301|HSPA12A
     1  MADKEAGGSD GPRETAPTSA YSSPARSLGD TGITPLSPSH IVNDTDSNVS EQQSFLVVVA
    61  VDFGTTSSGY AYSFTKEPEC IHVMRRWEGG DPGVSNQKTP TTILLTPERK FHSFGYAARD
   121  FYHDLDPNEA KQWLYLEKFK MKLHTTGDLT MDTDLTAANG KKVKALEIFA YALQYFKEQA
   181  LKELSDQAGS EFENSDVRWV ITVPAIWKQP AKQFMRQAAY QAGLASPENS EQLIIALEPE
   241  AASIYCRKLR LHQMIELSSK AAVNGYSGSD TVGAGFTQAK EHIRRNRQSR TFLVENVIGE
   301  IWSELEEGDK YVVVDSGGGT VDLTVHQIRL PEGHLKELYK ATGGPYGSLG VDYEFEKLLY
   361  KIFGEDFIEQ FKIKRPAAWV DLMIAFESRK RAAAPDRTNP LNITLPFSFI DYYKKFRGHS
   421  VEHALRKSNV DFVKWSSQGM LRMSPDAMNA LFKPTIDSII EHLRDLFQKP EVSTVKFLFL
   481  VGGFAEAPLL QQAVQAAFGD QCRIIIPQDV GLTILKGAVL FGLDPAVIKV RRSPLTYGVG
   541  VLNRYVEGKH PPEKLLVKDG TRWCTDVFDK FISADQSVAL GELVKRSYTP AKPSQLVIVI
   601  NIYSSEHDNV SFITDPGVKK CGTLRLDLTG TSGTAVPARR EIQTLMQFGD TEIKATAIDI
   661  ATSKSVKVGI DFLNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA12A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 27 nTPM
parathyroid gland: 19 nTPM
epididymis: 12 nTPM
adipose tissue: 11 nTPM
retina: 10 nTPM
ovary: 9.7 nTPM

Single-cell type

choroid plexus epithelial cells: 370 nCPM
podocytes: 323 nCPM
schwann cells: 318 nCPM
retinal ganglion cells: 313 nCPM
brain excitatory neurons: 240 nCPM
brain inhibitory neurons: 225 nCPM

Immune cell

naive B-cell: 1.8 nTPM
memory B-cell: 1.4 nTPM
T-reg: 1 nTPM
total PBMC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 96 nTPM
thalamus: 89 nTPM
medulla oblongata: 75 nTPM
pons: 71 nTPM
white matter: 67 nTPM
hippocampal formation: 67 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
gnomAD missense Z: 2.12
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

ATPase, nucleotide binding domain
Heat shock 70kDa protein 12A, nucleotide-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPA12A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA12A as an antibody target. Whether an autoantibody or antibody against HSPA12A could matter depends on whether native HSPA12A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA12A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPA12A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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