Seroatlas · Human Serome Atlas

HSPA2

Heat shock-related 70 kDa protein 2

Also known as: HSP72_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P54652
Gene: HSPA2
Ensembl: ENSG00000126803
Chromosome: 14
Canonical length: 639 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Perinuclear theca,Calyx,Flagellar centriole,Annulus

OverviewNCBI Gene

Enables enzyme binding activity and unfolded protein binding activity. Involved in negative regulation of inclusion body assembly and protein refolding. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

639 residues, UniProt reviewed canonical sequence.

>P54652|HSPA2
     1  MSARGPAIGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV
    61  AMNPTNTIFD AKRLIGRKFE DATVQSDMKH WPFRVVSEGG KPKVQVEYKG ETKTFFPEEI
   121  SSMVLTKMKE IAEAYLGGKV HSAVITVPAY FNDSQRQATK DAGTITGLNV LRIINEPTAA
   181  AIAYGLDKKG CAGGEKNVLI FDLGGGTFDV SILTIEDGIF EVKSTAGDTH LGGEDFDNRM
   241  VSHLAEEFKR KHKKDIGPNK RAVRRLRTAC ERAKRTLSSS TQASIEIDSL YEGVDFYTSI
   301  TRARFEELNA DLFRGTLEPV EKALRDAKLD KGQIQEIVLV GGSTRIPKIQ KLLQDFFNGK
   361  ELNKSINPDE AVAYGAAVQA AILIGDKSEN VQDLLLLDVT PLSLGIETAG GVMTPLIKRN
   421  TTIPTKQTQT FTTYSDNQSS VLVQVYEGER AMTKDNNLLG KFDLTGIPPA PRGVPQIEVT
   481  FDIDANGILN VTAADKSTGK ENKITITNDK GRLSKDDIDR MVQEAERYKS EDEANRDRVA
   541  AKNALESYTY NIKQTVEDEK LRGKISEQDK NKILDKCQEV INWLDRNQMA EKDEYEHKQK
   601  ELERVCNPII SKLYQGGPGG GSGGGGSGAS GGPTIEEVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 345 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 345 nTPM
skeletal muscle: 178 nTPM
midbrain: 146 nTPM
testis: 126 nTPM
hippocampal formation: 120 nTPM
colon: 97 nTPM

Single-cell type

extravillous trophoblasts: 733 nCPM
late primary spermatocytes: 716 nCPM
early primary spermatocytes: 453 nCPM
hepatic stellate cells: 194 nCPM
migrating cytotrophoblasts: 163 nCPM
oligodendrocytes: 152 nCPM

Immune cell

T-reg: 1.2 nTPM
neutrophil: 0.7 nTPM
gdT-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM
NK-cell: 0.3 nTPM
basophil: 0.2 nTPM

Brain region

white matter: 667 nTPM
medulla oblongata: 350 nTPM
basal ganglia: 310 nTPM
cerebellum: 288 nTPM
pons: 270 nTPM
spinal cord: 240 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSPA2.

Disease | ImmuneIEDB

Conditions an epitope on HSPA2 was assayed in.

multiple sclerosis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.05
gnomAD missense Z: 3.72
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA2 as an antibody target. Whether an autoantibody or antibody against HSPA2 could matter depends on whether native HSPA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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