Seroatlas · Human Serome Atlas

GK

Glycerol kinase

Also known as: GK1, GKD, GLPK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P32189
Gene: GK
Ensembl: ENSG00000198814
Chromosome: X
Canonical length: 559 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>P32189|GK
     1  MAASKKAVLG PLVGAVDQGT SSTRFLVFNS KTAELLSHHQ VEIKQEFPRE GWVEQDPKEI
    61  LHSVYECIEK TCEKLGQLNI DISNIKAIGV SNQRETTVVW DKITGEPLYN AVVWLDLRTQ
   121  STVESLSKRI PGNNNFVKSK TGLPLSTYFS AVKLRWLLDN VRKVQKAVEE KRALFGTIDS
   181  WLIWSLTGGV NGGVHCTDVT NASRTMLFNI HSLEWDKQLC EFFGIPMEIL PNVRSSSEIY
   241  GLMKISHSVK AGALEGVPIS GCLGDQSAAL VGQMCFQIGQ AKNTYGTGCF LLCNTGHKCV
   301  FSDHGLLTTV AYKLGRDKPV YYALEGSVAI AGAVIRWLRD NLGIIKTSEE IEKLAKEVGT
   361  SYGCYFVPAF SGLYAPYWEP SARGIICGLT QFTNKCHIAF AALEAVCFQT REILDAMNRD
   421  CGIPLSHLQV DGGMTSNKIL MQLQADILYI PVVKPSMPET TALGAAMAAG AAEGVGVWSL
   481  EPEDLSAVTM ERFEPQINAE ESEIRYSTWK KAVMKSMGWV TTQSPESGDP SIFCSLPLGF
   541  FIVSSMVMLI GARYISGIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 98 nTPM

Expression across tissuesHPA

Tissue

kidney: 98 nTPM
small intestine: 82 nTPM
duodenum: 80 nTPM
liver: 67 nTPM
appendix: 46 nTPM
urinary bladder: 27 nTPM

Single-cell type

neutrophils: 3,827 nCPM
monocytes: 816 nCPM
enterocytes: 570 nCPM
cdc: 265 nCPM
macrophages: 246 nCPM
urothelial cells: 167 nCPM

Immune cell

neutrophil: 160 nTPM
classical monocyte: 20 nTPM
myeloid DC: 14 nTPM
T-reg: 12 nTPM
non-classical monocyte: 8.8 nTPM
eosinophil: 7.2 nTPM

Brain region

cerebral cortex: 40 nTPM
thalamus: 31 nTPM
choroid plexus: 23 nTPM
white matter: 20 nTPM
pons: 19 nTPM
medulla oblongata: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GK.

Disease | AllUniProt

Conditions GK is implicated in, by any mechanism.

Glycerol kinase deficiency (GKD) MIM:307030

Disease | GeneticClinVar

25 pathogenic / likely-pathogenic of 239 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 3.19
DepMap mean gene effect: 0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GK as an antibody target. Whether an autoantibody or antibody against GK could matter depends on whether native GK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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