HSPA6

Protein identityUniProt · HPA

UniProt accession

P17066

Gene

HSPA6

Ensembl

ENSG00000173110

Chromosome

1

Canonical length

643 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Vesicles,Perinuclear theca,Calyx,Flagellar centriole,Annulus

OverviewNCBI Gene

Enables several functions, including ATP hydrolysis activity; heat shock protein binding activity; and unfolded protein binding activity. Involved in cellular response to heat and protein refolding. Located in COP9 signalosome; centriole; and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>P17066|HSPA6
     1  MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ
    61  AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG GKPKVRVCYR GEDKTFYPEE
   121  ISSMVLSKMK ETAEAYLGQP VKHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA
   181  AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV
   241  NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT
   301  RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK LLQDFFNGKE
   361  LNKSINPDEA VAYGAAVQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA
   421  TIPTKQTQTF TTYSDNQPGV FIQVYEGERA MTKDNNLLGR FELSGIPPAP RGVPQIEVTF
   481  DIDANGILSV TATDRSTGKA NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA
   541  KNSLEAHVFH VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE
   601  LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

89 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSPA6.

Disease | ImmuneIEDB

Conditions an epitope on HSPA6 was assayed in.

• multiple sclerosis B cell
• breast cancer T cell
• skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.38

gnomAD pLI

0

gnomAD missense Z

-0.22

DepMap mean gene effect

-0.21

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to heat
• protein refolding
• response to unfolded protein

Molecular functions

• ATP binding
• ATP hydrolysis activity
• ATP-dependent protein folding chaperone
• enzyme binding
• heat shock protein binding
• protein folding chaperone
• unfolded protein binding

Cellular components

• blood microparticle
• centriole
• cytoplasm
• cytosol
• extracellular exosome
• extracellular region
• ficolin-1-rich granule lumen
• nucleus
• plasma membrane
• secretory granule lumen

Protein domainsUniProt · Pfam · InterPro

• Heat shock protein 70 family
• Heat shock protein 70, conserved site
• Heat shock protein 70kD, peptide-binding domain superfamily
• Heat shock protein 70kD, C-terminal domain superfamily
• ATPase, nucleotide binding domain
• Hsp70 protein

KeywordsUniProt

• ATP-binding
• Methylation
• Nucleotide-binding
• Stress response

InteractionsUniProt · HPA

Protein binding partners of HSPA6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• BAG4