XYLB

Protein identityUniProt · HPA

UniProt accession

O75191

Gene

XYLB

Ensembl

ENSG00000093217

Chromosome

3

Canonical length

536 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

536 residues, UniProt reviewed canonical sequence.

>O75191|XYLB
     1  MAEHAPRRCC LGWDFSTQQV KVVAVDAELN VFYEESVHFD RDLPEFGTQG GVHVHKDGLT
    61  VTSPVLMWVQ ALDIILEKMK ASGFDFSQVL ALSGAGQQHG SIYWKAGAQQ ALTSLSPDLR
   121  LHQQLQDCFS ISDCPVWMDS STTAQCRQLE AAVGGAQALS CLTGSRAYER FTGNQIAKIY
   181  QQNPEAYSHT ERISLVSSFA ASLFLGSYSP IDYSDGSGMN LLQIQDKVWS QACLGACAPH
   241  LEEKLSPPVP SCSVVGAISS YYVQRYGFPP GCKVVAFTGD NPASLAGMRL EEGDIAVSLG
   301  TSDTLFLWLQ EPMPALEGHI FCNPVDSQHY MALLCFKNGS LMREKIRNES VSRSWSDFSK
   361  ALQSTEMGNG GNLGFYFDVM EITPEIIGRH RFNTENHKVA AFPGDVEVRA LIEGQFMAKR
   421  IHAEGLGYRV MSKTKILATG GASHNREILQ VLADVFDAPV YVIDTANSAC VGSAYRAFHG
   481  LAGGTDVPFS EVVKLAPNPR LAATPSPGAS QVYEALLPQY AKLEQRILSQ TRGPPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against XYLB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.21

Highest tissue expression

31 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.3

gnomAD pLI

0

gnomAD missense Z

0.21

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• carbohydrate metabolic process
• D-glucuronate catabolic process to D-xylulose 5-phosphate
• D-xylose metabolic process
• generation of precursor metabolites and energy
• xylulose metabolic process
• xylulose catabolic process

Molecular functions

• ATP binding
• D-xylulokinase activity

Cellular components

• cytosol

Protein domainsUniProt · Pfam · InterPro

• Carbohydrate kinase, FGGY
• Carbohydrate kinase FGGY, N-terminal
• Carbohydrate kinase FGGY, C-terminal
• ATPase, nucleotide binding domain
• FGGY family of carbohydrate kinases, N-terminal domain
• FGGY family of carbohydrate kinases, C-terminal domain
• D-xylulose kinase

KeywordsUniProt

• ATP-binding
• Carbohydrate metabolism
• Kinase
• Nucleotide-binding
• Transferase
• Xylose metabolism