Seroatlas · Human Serome Atlas

POTEE

POTE ankyrin domain family member E

Also known as: A26C1, A26C1A, CT104.2, POTE-2, POTE2, POTE2gamma, POTEE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6S8J3
Gene
POTEE
Ensembl
ENSG00000188219
Chromosome
2
Canonical length
1075 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Involved in substantia nigra development. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1075 residues, UniProt reviewed canonical sequence.

>Q6S8J3|POTEE
     1  MVVEVDSMPA ASSVKKPFGL RSKMGKWCCR CFPCYRESGK SNVGTSGDHD DSAMKTLRSK
    61  MGKWCHHCFP CCRGSGKSNV GASGDHDDSA MKTLRNKMGK WCCHCFPCCR GSGKSKVGAW
   121  GDYDDSAFME PRYHVRGEDL DKLHRAAWWG KVPRKDLIVM LRDTDVNKKD KQKRTALHLA
   181  SANGNSEVVK LLLDRRCQLN VLDNKKRTAL IKAVQCQEDE CALMLLEHGT DPNIPDEYGN
   241  TTLHYAIYNE DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
   301  LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH HVICQLLSDY
   361  KEKQMLKISS ENSNPEQELK LTSEEESQRF KGSENSQPEK MSQELEINKD GDREVEEEMK
   421  KHESNNVGLL ENLTNGVTAG NGDNGLIPQR KSRTPENQQF PDNESEEYHR ICELLSDYKE
   481  KQMPKYSSEN SNPEQDLKLT SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE
   541  EMKKHGSTHV GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
   601  KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDVLHENST LREEIAMLRL
   661  ELDTMKHQSQ LREKKYLEDI ESVKKKNDNL LKALQLNELT MDDDTAVLVI DNGSGMCKAG
   721  FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK ESYVGKEAQS KRGILTLKYP MEHGIITNWD
   781  DMEKIWHHTF YNELRVAPEE HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVP
   841  SLYTSGRTTG IVMDSGDGVT HTVPIYEGNA LPHATLRLDL AGRELPDYLM KILTERGYRF
   901  TTMAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI GNERFRCPEA
   961  LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS GGTTMYPGMA HRMQKEIAAL
  1021  APSMMKIRII APPKRKYSVW VGGSILASLS TFQQMWISKQ EYDESGPSIV HRKCF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
0.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.9 nTPM
  • prostate: 0.3 nTPM
  • blood vessel: 0.1 nTPM
  • colon: 0.1 nTPM
  • endometrium: 0.1 nTPM
  • placenta: 0.1 nTPM

Single-cell type

  • ependymal cells: 23 nCPM
  • prostatic glandular cells: 18 nCPM
  • breast hormone-responsive cells: 5 nCPM
  • late primary spermatocytes: 3.4 nCPM
  • differentiating spermatogonia: 2.7 nCPM
  • undifferentiated spermatogonia: 2.6 nCPM

Immune cell

  • total PBMC: 0.6 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • spinal cord: 4.1 nTPM
  • medulla oblongata: 2.5 nTPM
  • midbrain: 1 nTPM
  • pons: 0.7 nTPM
  • hypothalamus: 0.6 nTPM
  • hippocampal formation: 0.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POTEE.

Disease | ImmuneIEDB

Conditions an epitope on POTEE was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
-2.73
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEE as an antibody target. Whether an autoantibody or antibody against POTEE could matter depends on whether native POTEE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEE is annotated as secreted, so native POTEE circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label POTEE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/POTEE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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