Seroatlas · Human Serome Atlas

ACTR3C

Actin-related protein 3C

Also known as: ARP11, ARP3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0K3
Gene: ACTR3C
Ensembl: ENSG00000106526
Chromosome: 7
Canonical length: 210 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>Q9C0K3|ACTR3C
     1  MFESFNVPGL YIAVQAVLAL AASWTSRQVG ERTLTGIVID SGDGVTHVIP VAEGYVIGSC
    61  IKHIPIAGRD ITYFIQQLLR EREVGIPPEQ SLETAKAIKE KYCYICPDIV KEFAKYDVDP
   121  QKWIKQYTGI NAINQKKFVI DVGYERFLGP EIFFHPEFAN PDSMESISDV VDEVIQNCPI
   181  DVRRPLYKME QIPLSYPQGH GFHPLSPPFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 53 nTPM
liver: 19 nTPM
choroid plexus: 15 nTPM
pancreas: 12 nTPM
kidney: 11 nTPM
adrenal gland: 10 nTPM

Single-cell type

distal convoluted tubule cells: 213 nCPM
renal connecting tubule cells: 193 nCPM
renal collecting duct intercalated cells: 170 nCPM
loop of henle epithelial cells: 159 nCPM
choroid plexus epithelial cells: 155 nCPM
salivary ionocytes: 152 nCPM

Immune cell

gdT-cell: 4.7 nTPM
naive B-cell: 4.6 nTPM
naive CD4 T-cell: 4.1 nTPM
memory CD4 T-cell: 3.8 nTPM
memory B-cell: 3.3 nTPM
naive CD8 T-cell: 3.3 nTPM

Brain region

choroid plexus: 57 nTPM
hippocampal formation: 17 nTPM
basal ganglia: 16 nTPM
cerebral cortex: 14 nTPM
midbrain: 14 nTPM
pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR3C as an antibody target. Whether an autoantibody or antibody against ACTR3C could matter depends on whether native ACTR3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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