Seroatlas · Human Serome Atlas

PANK1

Pantothenate kinase 1

Also known as: MGC24596, PANK, PANK1_HUMAN, PANK1a, PANK1b

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TE04
Gene: PANK1
Ensembl: ENSG00000152782
Chromosome: 10
Canonical length: 598 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a member of the pantothenate kinase family. Pantothenate kinases are key regulatory enzymes in the biosynthesis of coenzyme A (CoA). The encoded protein catalyzes the first and rate-limiting enzymatic reaction in CoA biosynthesis and is regulated by CoA through feedback inhibition. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene and an intronic miRNA on the same strand are co-regulated by the tumor suppressor p53 (see PMID 20833636). [provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

598 residues, UniProt reviewed canonical sequence.

>Q8TE04|PANK1
     1  MLKLVGGGGG QDWACSVAGT SLGGEEAAFE VARPGDQGKA GGGSPGWGCA GIPDSAPGAG
    61  VLQAGAVGPA RGGQGAEEVG ESAGGGEERR VRHPQAPALR LLNRKPQGGS GEIKTPENDL
   121  QRGRLSRGPR TAPPAPGMGD RSGQQERSVP HSPGAPVGTS AAAVNGLLHN GFHPPPVQPP
   181  HVCSRGPVGG SDAAPQRLPL LPELQPQPLL PQHDSPAKKC RLRRRMDSGR KNRPPFPWFG
   241  MDIGGTLVKL VYFEPKDITA EEEQEEVENL KSIRKYLTSN TAYGKTGIRD VHLELKNLTM
   301  CGRKGNLHFI RFPSCAMHRF IQMGSEKNFS SLHTTLCATG GGAFKFEEDF RMIADLQLHK
   361  LDELDCLIQG LLYVDSVGFN GKPECYYFEN PTNPELCQKK PYCLDNPYPM LLVNMGSGVS
   421  ILAVYSKDNY KRVTGTSLGG GTFLGLCCLL TGCETFEEAL EMAAKGDSTN VDKLVKDIYG
   481  GDYERFGLQG SAVASSFGNM MSKEKRDSIS KEDLARATLV TITNNIGSIA RMCALNENID
   541  RVVFVGNFLR INMVSMKLLA YAMDFWSKGQ LKALFLEHEG YFGAVGALLE LFKMTDDK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PANK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 103 nTPM

Expression across tissuesHPA

Tissue

liver: 103 nTPM
kidney: 43 nTPM
tongue: 26 nTPM
duodenum: 19 nTPM
rectum: 16 nTPM
small intestine: 16 nTPM

Single-cell type

hepatocytes: 251 nCPM
myonuclei: 131 nCPM
choroid plexus epithelial cells: 127 nCPM
proximal tubule cells: 96 nCPM
cardiomyocytes: 96 nCPM
distal convoluted tubule cells: 62 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
memory CD8 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM

Brain region

choroid plexus: 25 nTPM
cerebellum: 18 nTPM
cerebral cortex: 12 nTPM
thalamus: 10 nTPM
pons: 10 nTPM
midbrain: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 1.59
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

coenzyme A biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PANK1 as an antibody target. Whether an autoantibody or antibody against PANK1 could matter depends on whether native PANK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PANK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PANK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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