PANK4

Protein identityUniProt · HPA

UniProt accession

Q9NVE7

Gene

PANK4

Ensembl

ENSG00000157881

Chromosome

1

Canonical length

773 aa

Protein class

Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

773 residues, UniProt reviewed canonical sequence.

>Q9NVE7|PANK4
     1  MAECGASGSG SSGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY YSTVQHKVAK
    61  VRSFDHSGKD TEREHEPPYE ISVQEEITAR LHFIKFENTY IEACLDFIKD HLVNTETKVI
   121  QATGGGAYKF KDLIEEKLRL KVDKEDVMTC LIKGCNFVLK NIPHEAFVYQ KDSDPEFRFQ
   181  TNHPHIFPYL LVNIGSGVSI VKVETEDRFE WVGGSSIGGG TFWGLGALLT KTKKFDELLH
   241  LASRGQHSNV DMLVRDVYGG AHQTLGLSGN LIASSFGKSA TADQEFSKED MAKSLLHMIS
   301  NDIGQLACLH ARLHSLDRVY FGGFFIRGHP VTMRTITYSI NFFSKGEVQA LFLRHEGYLG
   361  AIGAFLKGAE QDNPNQYSWG ENYAGSSGLM SASPELGPAQ RARSGTFDLL EMDRLERPLV
   421  DLPLLLDPPS YVPDTVDLTD DALARKYWLT CFEEALDGVV KRAVASQPDS VDAAERAEKF
   481  RQKYWNKLQT LRQQPFAYGT LTVRSLLDTR EHCLNEFNFP DPYSKVKQRE NGVALRCFPG
   541  VVRSLDALGW EERQLALVKG LLAGNVFDWG AKAVSAVLES DPYFGFEEAK RKLQERPWLV
   601  DSYSEWLQRL KGPPHKCALI FADNSGIDII LGVFPFVREL LLRGTEVILA CNSGPALNDV
   661  THSESLIVAE RIAGMDPVVH SALQEERLLL VQTGSSSPCL DLSRLDKGLA ALVRERGADL
   721  VVIEGMGRAV HTNYHAALRC ESLKLAVIKN AWLAERLGGR LFSVIFKYEV PAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PANK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

32 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PANK4.

Disease | AllUniProt

Conditions PANK4 is implicated in, by any mechanism.

• Cataract 49 (CTRCT49) MIM:619593

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 124 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cataract 49

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.3

gnomAD pLI

0.98

gnomAD missense Z

2.42

DepMap mean gene effect

0

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• coenzyme A biosynthetic process
• pantothenate metabolic process

Molecular functions

• ATP binding
• metal ion binding
• phosphatase activity

Cellular components

• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Damage-control phosphatase ARMT1-like, metal-binding domain
• Type II pantothenate kinase
• Damage-control phosphatase ARMT1-like, metal-binding domain superfamily
• ATPase, nucleotide binding domain
• Damage-control phosphatase ARMT1-like domain
• Fumble
• Pantothenate kinase, acetyl-CoA regulated, two-domain type
• At2g17340, three-helix bundle domain

KeywordsUniProt

• Acetylation
• ATP-binding
• Cataract
• Coenzyme A biosynthesis
• Cytoplasm
• Hydrolase
• Manganese
• Metal-binding
• Nickel
• Nitration
• Nucleotide-binding
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of PANK4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PKM