Seroatlas · Human Serome Atlas

HSPA9

Stress-70 protein, mitochondrial

Also known as: GRP75, HSPA9_HUMAN, HSPA9B, mot-2, mthsp75, PBP74

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P38646
Gene
HSPA9
Ensembl
ENSG00000113013
Chromosome
5
Canonical length
679 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

679 residues, UniProt reviewed canonical sequence.

>P38646|HSPA9
     1  MISASRAAAA RLVGAAASRG PTAARHQDSW NGLSHEAFRL VSRRDYASEA IKGAVVGIDL
    61  GTTNSCVAVM EGKQAKVLEN AEGARTTPSV VAFTADGERL VGMPAKRQAV TNPNNTFYAT
   121  KRLIGRRYDD PEVQKDIKNV PFKIVRASNG DAWVEAHGKL YSPSQIGAFV LMKMKETAEN
   181  YLGHTAKNAV ITVPAYFNDS QRQATKDAGQ ISGLNVLRVI NEPTAAALAY GLDKSEDKVI
   241  AVYDLGGGTF DISILEIQKG VFEVKSTNGD TFLGGEDFDQ ALLRHIVKEF KRETGVDLTK
   301  DNMALQRVRE AAEKAKCELS SSVQTDINLP YLTMDSSGPK HLNMKLTRAQ FEGIVTDLIR
   361  RTIAPCQKAM QDAEVSKSDI GEVILVGGMT RMPKVQQTVQ DLFGRAPSKA VNPDEAVAIG
   421  AAIQGGVLAG DVTDVLLLDV TPLSLGIETL GGVFTKLINR NTTIPTKKSQ VFSTAADGQT
   481  QVEIKVCQGE REMAGDNKLL GQFTLIGIPP APRGVPQIEV TFDIDANGIV HVSAKDKGTG
   541  REQQIVIQSS GGLSKDDIEN MVKNAEKYAE EDRRKKERVE AVNMAEGIIH DTETKMEEFK
   601  DQLPADECNK LKEEISKMRE LLARKDSETG ENIRQAASSL QQASLKLFEM AYKKMASERE
   661  GSGSSGTGEQ KEDQKEEKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
181 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 181 nTPM
  • skeletal muscle: 181 nTPM
  • parathyroid gland: 159 nTPM
  • liver: 137 nTPM
  • adrenal gland: 117 nTPM
  • heart muscle: 112 nTPM

Single-cell type

  • esophageal apical cells: 621 nCPM
  • esophageal basal cells: 289 nCPM
  • cytotrophoblasts: 281 nCPM
  • migrating cytotrophoblasts: 268 nCPM
  • adrenal cortex cells: 256 nCPM
  • pancreatic acinar cells: 237 nCPM

Immune cell

  • total PBMC: 54 nTPM
  • MAIT T-cell: 46 nTPM
  • myeloid DC: 42 nTPM
  • gdT-cell: 40 nTPM
  • non-classical monocyte: 39 nTPM
  • memory CD8 T-cell: 37 nTPM

Brain region

  • choroid plexus: 106 nTPM
  • white matter: 103 nTPM
  • cerebellum: 99 nTPM
  • pons: 97 nTPM
  • cerebral cortex: 94 nTPM
  • spinal cord: 91 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSPA9.

Disease | AllUniProt

Conditions HSPA9 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 129 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Even-plus syndrome
  • Autosomal dominant sideroblastic anemia

Disease | ImmuneIEDB

Conditions an epitope on HSPA9 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.97
gnomAD missense Z
1.04
DepMap mean gene effect
-2.31
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPA9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA9 as an antibody target. Whether an autoantibody or antibody against HSPA9 could matter depends on whether native HSPA9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPA9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSPA9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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