Seroatlas · Human Serome Atlas

ACTR8

Actin-related protein 8

Also known as: ARP8, ARP8_HUMAN, INO80N

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H981
Gene
ACTR8
Ensembl
ENSG00000113812
Chromosome
3
Canonical length
624 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to enable ATP binding activity. Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in centrosome and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

624 residues, UniProt reviewed canonical sequence.

>Q9H981|ACTR8
     1  MTQAEKGDTE NGKEKGGEKE KEQRGVKRPI VPALVPESLQ EQIQSNFIIV IHPGSTTLRI
    61  GRATDTLPAS IPHVIARRHK QQGQPLYKDS WLLREGLNKP ESNEQRQNGL KMVDQAIWSK
   121  KMSNGTRRIP VSPEQARSYN KQMRPAILDH CSGNKWTNTS HHPEYLVGEE ALYVNPLDCY
   181  NIHWPIRRGQ LNIHPGPGGS LTAVLADIEV IWSHAIQKYL EIPLKDLKYY RCILLIPDIY
   241  NKQHVKELVN MILMKMGFSG IVVHQESVCA TYGSGLSSTC IVDVGDQKTS VCCVEDGVSH
   301  RNTRLCLAYG GSDVSRCFYW LMQRAGFPYR ECQLTNKMDC LLLQHLKETF CHLDQDISGL
   361  QDHEFQIRHP DSPALLYQFR LGDEKLQAPM ALFYPATFGI VGQKMTTLQH RSQGDPEDPH
   421  DEHYLLATQS KQEQSAKATA DRKSASKPIG FEGDLRGQSS DLPERLHSQE VDLGSAQGDG
   481  LMAGNDSEEA LTALMSRKTA ISLFEGKALG LDKAILHSID CCSSDDTKKK MYSSILVVGG
   541  GLMFHKAQEF LQHRILNKMP PSFRRIIENV DVITRPKDMD PRLIAWKGGA VLACLDTTQE
   601  LWIYQREWQR FGVRMLRERA AFVW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • heart muscle: 17 nTPM
  • choroid plexus: 16 nTPM
  • tonsil: 14 nTPM
  • parathyroid gland: 14 nTPM
  • lymph node: 13 nTPM

Single-cell type

  • late spermatids: 133 nCPM
  • late primary spermatocytes: 60 nCPM
  • megakaryocytes: 43 nCPM
  • early spermatids: 42 nCPM
  • oocytes: 37 nCPM
  • tuft cells: 35 nCPM

Immune cell

  • basophil: 56 nTPM
  • NK-cell: 15 nTPM
  • T-reg: 15 nTPM
  • intermediate monocyte: 12 nTPM
  • myeloid DC: 11 nTPM
  • eosinophil: 11 nTPM

Brain region

  • choroid plexus: 30 nTPM
  • cerebellum: 25 nTPM
  • midbrain: 23 nTPM
  • hypothalamus: 23 nTPM
  • white matter: 23 nTPM
  • spinal cord: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
1.23
DepMap mean gene effect
-0.5
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTR8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR8 as an antibody target. Whether an autoantibody or antibody against ACTR8 could matter depends on whether native ACTR8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACTR8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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