Seroatlas · Human Serome Atlas

PANK3

Pantothenate kinase 3

Also known as: FLJ12899, PANK3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H999
Gene: PANK3
Ensembl: ENSG00000120137
Chromosome: 5
Canonical length: 370 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

370 residues, UniProt reviewed canonical sequence.

>Q9H999|PANK3
     1  MKIKDAKKPS FPWFGMDIGG TLVKLSYFEP IDITAEEEQE EVESLKSIRK YLTSNVAYGS
    61  TGIRDVHLEL KDLTLFGRRG NLHFIRFPTQ DLPTFIQMGR DKNFSTLQTV LCATGGGAYK
   121  FEKDFRTIGN LHLHKLDELD CLVKGLLYID SVSFNGQAEC YYFANASEPE RCQKMPFNLD
   181  DPYPLLVVNI GSGVSILAVH SKDNYKRVTG TSLGGGTFLG LCSLLTGCES FEEALEMASK
   241  GDSTQADKLV RDIYGGDYER FGLPGWAVAS SFGNMIYKEK RESVSKEDLA RATLVTITNN
   301  IGSVARMCAV NEKINRVVFV GNFLRVNTLS MKLLAYALDY WSKGQLKALF LEHEGYFGAV
   361  GALLGLPNFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PANK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

liver: 40 nTPM
duodenum: 39 nTPM
small intestine: 29 nTPM
colon: 25 nTPM
rectum: 24 nTPM
breast: 24 nTPM

Single-cell type

breast lactating cells: 202 nCPM
colonocytes: 110 nCPM
adrenal cortex cells: 109 nCPM
enterocytes: 109 nCPM
hepatocytes: 100 nCPM
breast hormone-responsive cells: 92 nCPM

Immune cell

non-classical monocyte: 1.7 nTPM
memory B-cell: 1.4 nTPM
intermediate monocyte: 1.2 nTPM
basophil: 1.1 nTPM
classical monocyte: 1 nTPM
plasmacytoid DC: 0.8 nTPM

Brain region

cerebellum: 67 nTPM
white matter: 45 nTPM
cerebral cortex: 45 nTPM
thalamus: 44 nTPM
midbrain: 44 nTPM
pons: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 2.5
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PANK3 as an antibody target. Whether an autoantibody or antibody against PANK3 could matter depends on whether native PANK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PANK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PANK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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