Seroatlas · Human Serome Atlas

HSPA12B

Heat shock 70 kDa protein 12B

Also known as: C20orf60, dJ1009E24.2, HS12B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MM6
Gene: HSPA12B
Ensembl: ENSG00000132622
Chromosome: 20
Canonical length: 686 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>Q96MM6|HSPA12B
     1  MLAVPEMGLQ GLYIGSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE VRAPQQASFS
    61  VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH QKTPTCLLLT PEGAFHSFGY
   121  TARDYYHDLD PEEARDWLYF EKFKMKIHSA TDLTLKTQLE AVNGKTMPAL EVFAHALRFF
   181  REHALQELRE QSPSLPEKDT VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS RENAEQLLIA
   241  LEPEAASVYC RKLRLHQLLD LSGRAPGGGR LGERRSIDSS FRQAREQLRR SRHSRTFLVE
   301  SGVGELWAEM QAGDRYVVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP YGAVGVDLAF
   361  EQLLCRIFGE DFIATFKRQR PAAWVDLTIA FEARKRTAGP HRAGALNISL PFSFIDFYRK
   421  QRGHNVETAL RRSSVNFVKW SSQGMLRMSC EAMNELFQPT VSGIIQHIEA LLARPEVQGV
   481  KLLFLVGGFA ESAVLQHAVQ AALGARGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP
   541  LTYGVGVLNR FVPGRHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG
   601  QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPADCG QDTAGAPPGR REIRAAMQFG
   661  DTEIKVTAVD VSTNRSVRAS IDFLSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA12B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 29 nTPM
spleen: 24 nTPM
adipose tissue: 22 nTPM
breast: 22 nTPM
lung: 20 nTPM
cervix: 15 nTPM

Single-cell type

vascular endothelial cells: 49 nCPM
lymphatic endothelial cells: 37 nCPM
late spermatids: 32 nCPM
fibro-adipogenic progenitors: 15 nCPM
peritubular myoid cells: 14 nCPM
late primary spermatocytes: 11 nCPM

Immune cell

non-classical monocyte: 0.8 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

thalamus: 16 nTPM
amygdala: 13 nTPM
basal ganglia: 13 nTPM
pons: 11 nTPM
medulla oblongata: 10 nTPM
midbrain: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
gnomAD missense Z: 2.27
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding

Protein domainsUniProt · Pfam · InterPro

ATPase, nucleotide binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HSPA12B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSPA12A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA12B as an antibody target. Whether an autoantibody or antibody against HSPA12B could matter depends on whether native HSPA12B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA12B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPA12B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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