Seroatlas · Human Serome Atlas

POTEKP

Putative beta-actin-like protein 3

Also known as: ACTBM_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BYX7
Gene: POTEKP
Canonical length: 375 aa

OverviewNCBI Gene

No narrative summary is available for POTEKP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q9BYX7|POTEKP
     1  MDDDTAVLVI DNGSGMCKAG FAGDDAPQAV FPSIVGRPRH QGMMEGMHQK ESYVGKEAQS
    61  KRGMLTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE HPILLTEAPL NPKANREKMT
   121  QIMFETFNTP AMYVAIQAVL SLYTSGRTTG IVMDSGDGFT HTVPIYEGNA LPHATLRLDL
   181  AGRELTDYLM KILTERGYRF TTTAEQEIVR DIKEKLCYVA LDSEQEMAMA ASSSSVEKSY
   241  ELPDGQVITI GNERFRCPEA LFQPCFLGME SCGIHKTTFN SIVKSDVDIR KDLYTNTVLS
   301  GGTTMYPGIA HRMQKEITAL APSIMKIKII APPKRKYSVW VGGSILASLS TFQQMWISKQ
   361  EYDESGPSIV HRKCF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEKP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about POTEKP.

Disease | ImmuneIEDB

Conditions an epitope on POTEKP was assayed in.

multiple sclerosis B cell
onchocerciasis B cell

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of POTEKP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEKP as an antibody target. Whether an autoantibody or antibody against POTEKP could matter depends on whether native POTEKP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEKP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label POTEKP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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