Seroatlas · Human Serome Atlas

ACTL6A

Actin-like protein 6A

Also known as: ACL6A_HUMAN, Actl6, Arp4, BAF53A, INO80K, SMARCN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O96019
Gene: ACTL6A
Ensembl: ENSG00000136518
Chromosome: 3
Canonical length: 429 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

429 residues, UniProt reviewed canonical sequence.

>O96019|ACTL6A
     1  MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK
    61  GKQGGPTYYI DTNALRVPRE NMEAISPLKN GMVEDWDSFQ AILDHTYKMH VKSEASLHPV
   121  LMSEAPWNTR AKREKLTELM FEHYNIPAFF LCKTAVLTAF ANGRSTGLIL DSGATHTTAI
   181  PVHDGYVLQQ GIVKSPLAGD FITMQCRELF QEMNIELVPP YMIASKEAVR EGSPANWKRK
   241  EKLPQVTRSW HNYMCNCVIQ DFQASVLQVS DSTYDEQVAA QMPTVHYEFP NGYNCDFGAE
   301  RLKIPEGLFD PSNVKGLSGN TMLGVSHVVT TSVGMCDIDI RPGLYGSVIV AGGNTLIQSF
   361  TDRLNRELSQ KTPPSMRLKL IANNTTVERR FSSWIGGSIL ASLGTFQQMW ISKQEYEEGG
   421  KQCVERKCP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTL6A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

testis: 58 nTPM
thymus: 43 nTPM
tonsil: 39 nTPM
rectum: 36 nTPM
ovary: 32 nTPM
breast: 31 nTPM

Single-cell type

late primary spermatocytes: 327 nCPM
oocytes: 309 nCPM
early primary spermatocytes: 192 nCPM
differentiating spermatogonia: 123 nCPM
gastric progenitor cells: 101 nCPM
extravillous trophoblasts: 87 nCPM

Immune cell

T-reg: 39 nTPM
myeloid DC: 34 nTPM
MAIT T-cell: 32 nTPM
naive CD8 T-cell: 31 nTPM
naive CD4 T-cell: 30 nTPM
non-classical monocyte: 30 nTPM

Brain region

white matter: 13 nTPM
choroid plexus: 12 nTPM
medulla oblongata: 11 nTPM
cerebellum: 9.7 nTPM
midbrain: 9.1 nTPM
basal ganglia: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 1
gnomAD missense Z: 2.94
DepMap mean gene effect: -1.59
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 18% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTL6A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTL6A as an antibody target. Whether an autoantibody or antibody against ACTL6A could matter depends on whether native ACTL6A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTL6A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTL6A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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