Seroatlas · Human Serome Atlas

HSPA7

Putative heat shock 70 kDa protein 7

Also known as: HSP77_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48741
Gene: HSPA7
Canonical length: 367 aa

OverviewNCBI Gene

No narrative summary is available for HSPA7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

367 residues, UniProt reviewed canonical sequence.

>P48741|HSPA7
     1  MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ
    61  AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFQVVSEG GKPKVRVCYR GEDKTFYPEE
   121  ISSMVLSKMK ETAEAYLGQP VKHAVITVPT YFSNSQRQAT KDAGAIAGLK VLPIINEATA
   181  AAIAYGLDRR GAGKRNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV
   241  NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTPSSST QATLEIDSLF EGVDFYKSIT
   301  RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDFVLGG GLHSHPQGAE VAAGLLQRQG
   361  AEQEHQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27

OntologyGO

Biological processes

protein refolding

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPA7 as an antibody target. Whether an autoantibody or antibody against HSPA7 could matter depends on whether native HSPA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPA7 is annotated at the cell surface, where native HSPA7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HSPA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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