Seroatlas · Human Serome Atlas

ACTR3B

Actin-related protein 3B

Also known as: ARP11, ARP3B_HUMAN, ARP3beta

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P1U1
Gene: ACTR3B
Ensembl: ENSG00000133627
Chromosome: 7
Canonical length: 418 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q9P1U1|ACTR3B
     1  MAGSLPPCVV DCGTGYTKLG YAGNTEPQFI IPSCIAIRES AKVVDQAQRR VLRGVDDLDF
    61  FIGDEAIDKP TYATKWPIRH GIIEDWDLME RFMEQVVFKY LRAEPEDHYF LMTEPPLNTP
   121  ENREYLAEIM FESFNVPGLY IAVQAVLALA ASWTSRQVGE RTLTGIVIDS GDGVTHVIPV
   181  AEGYVIGSCI KHIPIAGRDI TYFIQQLLRE REVGIPPEQS LETAKAIKEK YCYICPDIVK
   241  EFAKYDVDPR KWIKQYTGIN AINQKKFVID VGYERFLGPE IFFHPEFANP DFMESISDVV
   301  DEVIQNCPID VRRPLYKNVV LSGGSTMFRD FGRRLQRDLK RVVDARLRLS EELSGGRIKP
   361  KPVEVQVVTH HMQRYAVWFG GSMLASTPEF FQVCHTKKDY EEYGPSICRH NPVFGVMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 52 nTPM
cerebral cortex: 34 nTPM
hippocampal formation: 31 nTPM
amygdala: 23 nTPM
cerebellum: 19 nTPM
hypothalamus: 17 nTPM

Single-cell type

platelets: 195 nCPM
somatotrophs: 141 nCPM
myonuclei: 130 nCPM
lactotrophs: 85 nCPM
breast lactating cells: 84 nCPM
breast secretory cells: 74 nCPM

Immune cell

naive CD4 T-cell: 1.8 nTPM
memory CD8 T-cell: 1.7 nTPM
T-reg: 1.4 nTPM
NK-cell: 1.2 nTPM
total PBMC: 1.2 nTPM
MAIT T-cell: 1 nTPM

Brain region

hippocampal formation: 59 nTPM
basal ganglia: 53 nTPM
cerebral cortex: 51 nTPM
white matter: 41 nTPM
hypothalamus: 38 nTPM
amygdala: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 2.97
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTR3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR3B as an antibody target. Whether an autoantibody or antibody against ACTR3B could matter depends on whether native ACTR3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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