Seroatlas · Human Serome Atlas

ACTR1A

Alpha-centractin

Also known as: ACTZ_HUMAN, ARP1, Arp1A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P61163
Gene: ACTR1A
Ensembl: ENSG00000138107
Chromosome: 10
Canonical length: 376 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>P61163|ACTR1A
     1  MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG ALEGDIFIGP
    61  KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPRKN
   121  RERAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI
   181  MRIDIAGRDV SRFLRLYLRK EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ
   241  YYLPDGSTIE IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL
   301  SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL DTFKKMWVSK
   361  KEYEEDGARS IHRKTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 166 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 166 nTPM
tongue: 119 nTPM
cerebral cortex: 97 nTPM
hypothalamus: 89 nTPM
heart muscle: 89 nTPM
spinal cord: 88 nTPM

Single-cell type

esophageal apical cells: 183 nCPM
syncytiotrophoblasts: 158 nCPM
late primary spermatocytes: 109 nCPM
esophageal suprabasal cells: 99 nCPM
hofbauer cells: 98 nCPM
neutrophils: 97 nCPM

Immune cell

non-classical monocyte: 57 nTPM
intermediate monocyte: 52 nTPM
eosinophil: 44 nTPM
classical monocyte: 41 nTPM
myeloid DC: 41 nTPM
total PBMC: 39 nTPM

Brain region

pons: 120 nTPM
medulla oblongata: 117 nTPM
hypothalamus: 103 nTPM
midbrain: 100 nTPM
cerebral cortex: 98 nTPM
white matter: 94 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACTR1A.

Disease | ImmuneIEDB

Conditions an epitope on ACTR1A was assayed in.

multiple sclerosis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.97
gnomAD missense Z: 3.03
DepMap mean gene effect: -0.75
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

vesicle-mediated transport

Molecular functions

ATP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTR1A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR1A as an antibody target. Whether an autoantibody or antibody against ACTR1A could matter depends on whether native ACTR1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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