Seroatlas · Human Serome Atlas

POTEJ

POTE ankyrin domain family member J

Also known as: POTE2beta, POTEJ_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CG39
Gene: POTEJ
Ensembl: ENSG00000222038
Chromosome: 2
Canonical length: 1038 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be involved in axonogenesis and cell motility. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1038 residues, UniProt reviewed canonical sequence.

>P0CG39|POTEJ
     1  MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD DSTMKTLRSK
    61  MGKWCCHCFP CCRGSGKSNV GAWGDYDDSA FVEPRYHVRR EDLDKLHRAA WWGKVARKDL
   121  IVMLRDTDVN KQDKQKRTAL HLASANGNSG VVKLLLDRRC QLNVLDNKKR TALTKAVQCQ
   181  EDECALMLLE HGTDPNIPDE YGNTTLHYAI YNEDKLMAKA LLLYGADIES KNKHGLTPLL
   241  LGVHEQKQQV VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVSLLLEQ NIDVSSQDLS
   301  GQTAREYAVS SHHHVICQLL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES QRFKGSENSQ
   361  PEKMSQEPEI NKDGDREVEE EMKKHESNNV GLLENLSNGV TAGNGDDGLI PQRKSRTPEN
   421  QQFPDNESEE YHRICELVSD YKEKQMPKYS SENSNPEQDL KLTSEEESQR LKGSENGQPE
   481  KRSQEPEINK DGDRELENFM AIEEMKKHGS THVGFPENLT NGATAGNGDD GLIPPRKSRT
   541  PESQQFPDTE NEEYHSDEQN DTQKQFCEEQ NTGILHDEIL IHEEKQIEVV EKMNSELSLS
   601  CKKERDFLHE NSMLREEIAM LRLELDTMKH QSQLRKKKYL EDIESVKKKN DNLLKALQLN
   661  ELTMDDDTAV LVIDNGSGMC KAGFAGDDAP RAVFPSIVGC PRQQGMMGGM HQKESYVGKE
   721  AQSKRGILTL KYPMEHGIIT NWDDMEKIWH HTFYNELRVA PEEHPILLTE APLNPKANRE
   781  KMTQIMFETF NTPAMYVAIQ AMLSLYTSGR TTGIVMDSGD GVTHTVPIYD GNALPHATLR
   841  LDLAGRELTD YLMKILTERG YRFTTMAERE IVRDIKEKLC YVALDFEQEM AMVASSSSLE
   901  KSYELPDGQV ITISNEWFRC PEALFQPCFL GMESCGIHET TFNSIMKSDV DIRKDLYTNT
   961  VLSGGTTMYP GMAHRMQKEI AALAPSMMKI RIIAPPKRKY SVWVGGSILA SLSTFQQMWI
  1021  SKQEYDESGP SIVHRKCF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against POTEJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

testis: 0.8 nTPM
prostate: 0.6 nTPM
heart muscle: 0.1 nTPM
stomach: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

prostatic glandular cells: 30 nCPM
corticotrophs: 3.7 nCPM
early primary spermatocytes: 3.4 nCPM
somatotrophs: 2.7 nCPM
pancreatic islet cells: 2.6 nCPM
late primary spermatocytes: 2.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 1 nTPM
spinal cord: 0.7 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: -2.31

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads POTEJ as an antibody target. Whether an autoantibody or antibody against POTEJ could matter depends on whether native POTEJ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

POTEJ is annotated as secreted, so native POTEJ circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label POTEJ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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