HSPA1L

Protein identityUniProt · HPA

UniProt accession

P34931

Gene

HSPA1L

Ensembl

ENSG00000204390

Chromosome

6

Canonical length

641 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Vesicles,Perinuclear theca,Calyx,Flagellar centriole,Annulus

OverviewNCBI Gene

This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

641 residues, UniProt reviewed canonical sequence.

>P34931|HSPA1L
     1  MATAKGIAIG IDLGTTYSCV GVFQHGKVEI IANDQGNRTT PSYVAFTDTE RLIGDAAKNQ
    61  VAMNPQNTVF DAKRLIGRKF NDPVVQADMK LWPFQVINEG GKPKVLVSYK GENKAFYPEE
   121  ISSMVLTKLK ETAEAFLGHP VTNAVITVPA YFNDSQRQAT KDAGVIAGLN VLRIINEPTA
   181  AAIAYGLDKG GQGERHVLIF DLGGGTFDVS ILTIDDGIFE VKATAGDTHL GGEDFDNRLV
   241  SHFVEEFKRK HKKDISQNKR AVRRLRTACE RAKRTLSSST QANLEIDSLY EGIDFYTSIT
   301  RARFEELCAD LFRGTLEPVE KALRDAKMDK AKIHDIVLVG GSTRIPKVQR LLQDYFNGRD
   361  LNKSINPDEA VAYGAAVQAA ILMGDKSEKV QDLLLLDVAP LSLGLETAGG VMTALIKRNS
   421  TIPTKQTQIF TTYSDNQPGV LIQVYEGERA MTKDNNLLGR FDLTGIPPAP RGVPQIEVTF
   481  DIDANGILNV TATDKSTGKV NKITITNDKG RLSKEEIERM VLDAEKYKAE DEVQREKIAA
   541  KNALESYAFN MKSVVSDEGL KGKISESDKN KILDKCNELL SWLEVNQLAE KDEFDHKRKE
   601  LEQMCNPIIT KLYQGGCTGP ACGTGYVPGR PATGPTIEEV D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPA1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

55 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HSPA1L.

Disease | ImmuneIEDB

Conditions an epitope on HSPA1L was assayed in.

• multiple sclerosis B cell
• allergic disease T cell
• Timothy grass allergy T cell
• Chagas disease B cell
• type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0

gnomAD missense Z

0.64

DepMap mean gene effect

0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• binding of sperm to zona pellucida
• positive regulation of protein targeting to mitochondrion
• protein refolding
• response to unfolded protein

Molecular functions

• ATP binding
• ATP hydrolysis activity
• ATP-dependent protein folding chaperone
• heat shock protein binding
• protein folding chaperone
• ubiquitin protein ligase binding
• unfolded protein binding

Cellular components

• blood microparticle
• cell body
• cytoplasm
• cytosol
• nucleoplasm
• nucleus
• plasma membrane
• zona pellucida receptor complex

Protein domainsUniProt · Pfam · InterPro

• Heat shock protein 70 family
• Heat shock protein 70, conserved site
• Heat shock protein 70kD, peptide-binding domain superfamily
• Heat shock protein 70kD, C-terminal domain superfamily
• ATPase, nucleotide binding domain
• Hsp70 protein

KeywordsUniProt

• ATP-binding
• Nucleotide-binding

InteractionsUniProt · HPA

Protein binding partners of HSPA1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PRKN
• BAG4
• CLTA
• DNAJA1
• DNAJB1
• DNAJB4
• DNAJC7
• TP53