Seroatlas · Human Serome Atlas

ACTR2

Actin-related protein 2

Also known as: ARP2, ARP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P61160
Gene
ACTR2
Ensembl
ENSG00000138071
Chromosome
2
Canonical length
394 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

394 residues, UniProt reviewed canonical sequence.

>P61160|ACTR2
     1  MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI EIKDLMVGDE
    61  ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI DTRNCKILLT EPPMNPTKNR
   121  EKIVEVMFET YQFSGVYVAI QAVLTLYAQG LLTGVVVDSG DGVTHICPVY EGFSLPHLTR
   181  RLDIAGRDIT RYLIKLLLLR GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL
   241  VESYTLPDGR IIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRSEFYKH
   301  IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR KHMVFLGGAV
   361  LADIMKDKDN FWMTRQEYQE KGVRVLEKLG VTVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACTR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
240 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 240 nTPM
  • lymph node: 230 nTPM
  • appendix: 203 nTPM
  • thymus: 169 nTPM
  • spleen: 161 nTPM
  • bone marrow: 138 nTPM

Single-cell type

  • neutrophils: 2,012 nCPM
  • neutrophil progenitors: 1,467 nCPM
  • monocyte progenitors: 1,097 nCPM
  • monocytes: 893 nCPM
  • kupffer cells: 698 nCPM
  • megakaryocytes: 593 nCPM

Immune cell

  • total PBMC: 290 nTPM
  • basophil: 280 nTPM
  • non-classical monocyte: 237 nTPM
  • neutrophil: 210 nTPM
  • intermediate monocyte: 207 nTPM
  • eosinophil: 185 nTPM

Brain region

  • white matter: 131 nTPM
  • cerebral cortex: 117 nTPM
  • hippocampal formation: 110 nTPM
  • spinal cord: 109 nTPM
  • hypothalamus: 109 nTPM
  • thalamus: 108 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ACTR2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 29 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
3.67
DepMap mean gene effect
-1.26
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ACTR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACTR2 as an antibody target. Whether an autoantibody or antibody against ACTR2 could matter depends on whether native ACTR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACTR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACTR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACTR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...